RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging.
RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging.
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DOI：
10.1016/j.jmb.2019.03.018
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发表时间：
2019-03
影响因子：
5.6
通讯作者：
M. Shafiuddin;A. Boon
中科院分区：
文献类型：
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作者：
M. Shafiuddin;A. Boon
甲型流感病毒（IAV）是人类呼吸道病原体，对全球医疗保健系统构成严重的医疗和经济挑战。IAV基因组由八个单链病毒RNA片段组成，通过称为基因组包装的复杂过程并入病毒体。病毒RNA片段内的特定RNA序列作为基因组包装所必需的信号。虽然有效的包装是病毒感染性的先决条件，但关于这一过程的许多机制细节仍然缺失。在这篇综述中，我们讨论了对IAV基因组包装的理解的最新进展，并专注于在这一过程中发挥作用的RNA特征。
The influenza A virus (IAV), a respiratory pathogen for humans, poses serious medical and economic challenges to global healthcare systems. The IAV genome, consisting of eight single-stranded viral RNA segments, is incorporated into virions by a complex process known as genome packaging. Specific RNA sequences within the viral RNA segments serve as signals that are necessary for genome packaging. Although efficient packaging is a prerequisite for viral infectivity, many of the mechanistic details about this process are still missing. In this review, we discuss the recent advances toward the understanding of IAV genome packaging and focus on the RNA features that play a role in this process.