Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.
Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.
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DOI：
10.1002/brb3.615
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发表时间：
2017-02
影响因子：
3.1
通讯作者：
Dougherty DM
中科院分区：
文献类型：
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作者：
Acheson A;Wijtenburg SA;Rowland LM;Winkler A;Mathias CW;Hong LE;Jahanshad N;Patel B;Thompson PM;McGuire SA;Sherman PM;Kochunov P;Dougherty DM
在准备对有物质使用障碍家族史(FH+)或没有此类病史(FH−)的年轻人的白质发育进行纵向分析时，我们检查了全球和区域分数各向异性(FA)值测量的重复性和可靠性，这些测量使用通过荟萃分析增强神经成像遗传学(EIGMA)-扩散张量成像(DTI)方案进行测量。要发现大脑发育中的任何细微差异，就必须采用高度可靠的测量方法。首先，我们分析了12名健康的年轻人(年龄20-28岁)在一周内进行了三次成像的重复性数据。接下来，我们计算了在68名FH+和21名FH−青少年样本中相隔一年收集的数据中的相同指标。这是一个时间框架，与受试者之间的差异相比，受试者内部白质微结构的变化很小。通过检查全球FA值和特定区域FA值的平均变异系数(MCV)、平均绝对差值(MAD)和组内相关性(ICC)来评估重复性。我们发现，除了成人和青少年的皮质脊髓束和穹隆外，全脑DTI-FA值和大多数白质束都具有很好的重复性。FH组对重复性无显著影响(p=4.4)。重复性指标在青少年和成人之间没有显著差异(均P>；2)。在事后分析中，区域FA值的再现性度量与Enigma-DTI以前报告的区域FA遗传力度量显示出强烈的正相关(r=5.6)。总体而言，这项研究证明了Enigma-DTI FA的良好重复性，将其作为纵向研究和其他重复评估脑白质微观结构的方案的可行分析工具。
In preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH−), we examined the reproducibility and reliability of global and regional measures of fractional anisotropy (FA) values, measured using the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA)‐diffusion tensor imaging (DTI) protocol. Highly reliable measures are necessary to detect any subtle differences in brain development. First, we analyzed reproducibility data in a sample of 12 healthy young adults (ages 20–28) imaged three times within a week. Next, we calculated the same metrics in data collected 1‐year apart in the sample of 68 FH+ and 21 FH− adolescents. This is a timeframe where within subject changes in white matter microstructure are small compared to between subject variance. Reproducibility was estimated by examining mean coefficients of variation (MCV), mean absolute differences (MAD), and intraclass correlations (ICC) for global and tract‐specific FA values. We found excellent reproducibility for whole‐brain DTI‐FA values and most of the white matter tracts, except for the corticospinal tract and the fornix in both adults and youths. There was no significant effect of FH‐group on reproducibility (p = .4). Reproducibility metrics were not significantly different between adolescents and adults (all p > .2). In post hoc analyses, the reproducibility metrics for regional FA values showed a strong positive correlation (r = .6) with the regional FA heritability measures previously reported by ENIGMA‐DTI. Overall, this study demonstrated an excellent reproducibility of ENIGMA‐DTI FA, positing it as viable analysis tools for longitudinal studies and other protocols that repeatedly assess white matter microstructure.