Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis
Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis
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DOI：
10.1128/aac.00004-14
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发表时间：
2014-07-01
影响因子：
4.9
通讯作者：
Jennings, Michael P.
中科院分区：
文献类型：
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作者：
Jen, Freda E. -C.;Seib, Kate L.;Jennings, Michael P.
相变化是适应宿主的细菌病原体如脑膜炎奈瑟菌的共同特征。最近，我们报道了这种基因表达的快速开关发生在DNA甲基转移酶中，通过全局甲基化的变化改变多个基因的表达。在本研究中，我们比较了具有ModA11、ModA12和ModD1相变的菌株的MIC值，揭示了由于ModA11和ModA12转换而导致的MIC差异，其中ModA11_OFF菌株显示出对头孢他啶和环丙沙星的4倍降低的亲和性。
Phase variation is a common feature of host-adapted bacterial pathogens such as Neisseria meningitidis. Recently, we reported that this rapid on/off switching of gene expression occurs in DNA methyltransferases, altering expression in multiple genes via changes in global methylation. In the current study, we compared MIC values of strains with ModA11, ModA12, and ModD1 phasevarions, revealing MIC differences due to ModA11 and ModA12 switching, with a ModA11_OFF strain showing 4-fold reduced susceptibilities to ceftazidime and ciprofloxacin.