Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes.
Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes.
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为人类认知表型的基因调控编织新的见解。
DOI：
10.1016/j.cell.2017.12.037
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发表时间：
2018
期刊：
影响因子：
64.5
通讯作者：
Dougherty,JosephD
中科院分区：
文献类型：
--
作者：
Mulvey,Bernard;Dougherty,JosephD
精神病学遗传学研究已经得出了人类认知特征和非编码基因组变异之间的关联。然而，这些变体的机制影响尚不清楚。通过编织来自发育中的人类大脑的基因组数据链，de la Torre-Ubieta et al.将疾病相关基因座与功能增强子、靶基因和受脓毒症影响的细胞类型联系起来。
Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these variants are unclear. By weaving in strands of genomic data from developing human brains, de la Torre-Ubieta et al. tie disease-associated loci to functional enhancers, target genes, and putatively affected cell types.