The fetal dermal but not loose fascial mesenchymal cells possess regenerative activity of dermal structure
The fetal dermal but not loose fascial mesenchymal cells possess regenerative activity of dermal structure
复制标题
DOI：
10.3727/000000005783982729
复制
发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Nakajima, T
中科院分区：
文献类型：
--
作者：
Kishi, K;Katsube, K;Nakajima, T
胎儿皮肤具有再生活性，直到某些发育阶段。然而，在创伤后再生真皮的细胞的来源尚未阐明。在本研究中，我们通过组织学检查和标记疏松筋膜中的细胞来定位重建胎儿真皮结构的细胞的来源。接下来，我们通过将胎儿真皮间充质细胞与胎儿表皮细胞共同移植到scid小鼠的皮肤缺损处，评估其再生活性。我们的结论是胎儿真皮间充质细胞，而不是松散的筋膜细胞具有再生活性，即使在scid小鼠的环境。
Fetal skin possesses a regenerative activity until certain developmental stages. However, the origin of cells that regenerate dermis after wounding has not been clarified yet. In the present study we located the origin of cells that reconstruct fetal dermal structure by histological examination and by marking cells in the loose fascia. Next we evaluated the regenerative activity of fetal dermal mesenchymal cells by cotransplanting with fetal epidermal cells onto the skin defect of scid mice. We conclude that fetal dermal mesenchymal cells but not loose fascial cells possess regenerative activity even on the environment in scid mice.