Experimental advances in the characterization of metazoan gene regulatory networks
Experimental advances in the characterization of metazoan gene regulatory networks
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DOI：
10.1093/bfgp/elp001
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Deplancke, Bart
中科院分区：
文献类型：
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作者：
Deplancke, Bart
基因调控网络（GRN）在后生动物的发育和功能中发挥着至关重要的作用，这些网络的失调通常与疾病有关。 GRN 描述了基因组和调控状态组件之间的动态相互作用。基因组成分包含基因及其相关的顺式调控元件。调节状态成分主要由结合后一元件的转录复合物组成。随着完整基因组序列的出现，最近开发了几种方法，这些方法有望显着增强我们识别基因组或调控状态成分或这两者之间相互作用的能力。在这篇综述中，我对这些方法进行了深入的概述，并详细介绍了每种方法如何有助于更全面地理解 GRN 的组成和功能。
Gene regulatory networks (GRNs) play a vital role in metazoan development and function, and deregulation of these networks is often implicated in disease. GRNs depict the dynamic interactions between genomic and regulatory state components. The genomic components comprise genes and their associated cis-regulatory elements. The regulatory state components consist primarily of transcriptional complexes that bind the latter elements. With the availability of complete genome sequences, several approaches have recently been developed which promise to significantly enhance our ability to identify either the genomic or regulatory state components, or the interactions between these two. In this review, I provide an in-depth overview of these approaches and detail how each contributes to a more comprehensive understanding of GRN composition and function.