The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study: study design and baseline factors.
The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study: study design and baseline factors.
复制标题
高眼压治疗研究的共焦扫描激光检眼镜辅助研究：研究设计和基线因素。
DOI：
10.1016/j.ajo.2003.08.031
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
OHTSCSLOAncillaryStudy
中科院分区：
文献类型：
--
作者：
Zangwill,LindaM;Weinreb,RobertN;Berry,CharlesC;Smith,AmandaR;Dirkes,KeriA;Liebmann,JeffreyM;Brandt,JamesD;Trick,Gary;Cioffi,GeorgeA;Coleman,AnneL;Piltz-Seymour,JodyR;Gordon,MaeO;Kass,MichaelA;OHTSCSLOAncillaryStudy
目的描述共聚焦扫描激光检眼镜检查（CSLO）辅助研究的研究设计，以眼高压治疗研究（OHTS），并检查视盘地形图之间的关联，和基线人口统计学，临床和眼部因素在研究entry. RIGNA随机临床试验. METHODS参与者在这一辅助研究招募从七个22 OHTS临床中心。每个参与者每年使用CSL 0，海德堡视网膜断层扫描仪（HRT）完成成像。HRT视盘地形测量值与眼内压（IOP）、OHTS视盘阅读中心水平和垂直杯-盘直径比的基线摄影估计值、基线视野指数、人口统计学和临床因素之间的相关性采用线性混合效应模型进行评估。HRT地形视盘测量值与糖尿病、全身性高血压、心血管疾病、IOP或视功能之间无相关性，HRT地形视盘测量值与水平和垂直杯盘直径比的基线立体摄影估计值相关。水平和垂直杯盘直径比的立体摄影评估与HRT杯盘面积比之间的关联最强（分别为r = 0.85和0.84），边缘-椎间盘面积比（分别为r =-0.85和-0.84），平均髋臼杯深度（分别为r = 0.84和0.83）和髋臼杯面积（分别为r = 0.83和0.80）。调整后的视盘面积，所有HRT地形视盘测量仍然与立体摄影评估水平和垂直杯盘直径ratio. CONCLUSIONSSThe CSLO辅助研究的OHTS是第一个多中心临床试验，使用CSLO成像监测视盘的变化。在研究开始时，HRT地形测量值与高眼压受试者水平和垂直立体摄影的杯盘直径比估计值吻合良好。
PURPOSETo describe the study design of the Confocal Scanning Laser Ophthalmoscopy (CSLO) Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) and to examine the associations between optic disk topography, and baseline demographic, clinical, and ocular factors at study entry.DESIGNA randomized clinical trial.METHODSParticipants in this ancillary study were recruited from seven of the 22 OHTS clinical centers. Each participant completed imaging annually using a CSLO, the Heidelberg Retina Tomograph (HRT). Associations between HRT topographic optic disk measurements and intraocular pressure (IOP), baseline photographic estimates of horizontal and vertical cup-to-disk diameter ratios by the OHTS Optic Disk Reading Center, baseline visual field indices, and demographic and clinical factors were assessed using linear mixed effects models.RESULTSFour hundred thirty-nine participants had good quality images and were included in this baseline analysis. No associations between HRT topographic optic disk measurements and diabetes, systemic hypertension, cardiovascular disease, IOP, or visual function were found. The HRT topographic optic disk measurements were associated with baseline stereophotographic estimates of horizontal and vertical cup-to-disk diameter ratios. The strongest associations were found between stereophotographic assessment of horizontal and vertical cup-to-disk diameter ratios, and HRT cup-to-disk area ratio (r = .85 and .84, respectively), rim-to-disk area ratio (r = −.85 and −.84, respectively), mean cup depth (r = .84 and .83, respectively), and cup area (r = .83 and .80, respectively). After adjusting for optic disk area, all HRT topographic optic disk measurements remained associated with stereophotographic assessment of horizontal and vertical cup-to-disk diameter ratios.CONCLUSIONSThe CSLO ancillary study to the OHTS is the first multicenter clinical trial to use CSLO imaging to monitor changes in the optic disk. At study entry, HRT topographic measurements corresponded well with both horizontal and vertical stereophotographic-based estimates of cup-to-disk diameter ratio in ocular hypertensive participants.