HIV Infection of Macrophages: Implications for Pathogenesis and Cure.
HIV Infection of Macrophages: Implications for Pathogenesis and Cure.
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DOI：
10.20411/pai.v2i2.204
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Walker, Bruce D
中科院分区：
文献类型：
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作者：
Clayton, Kiera L;Garcia, J Victor;Walker, Bruce D
尽管 CD4+ T 细胞是持续性 HIV 和 SIV 感染的主要储存库，但越来越多的证据表明巨噬细胞也有贡献。然而，在艾滋病毒发病机制和治疗会议上，对巨噬细胞作用的研究往往代表性不足。这也是 2017 年 1 月在马萨诸塞州剑桥举办的专门针对这一研究领域的科学研讨会的推动力。该研讨会汇集了 HIV/SIV 免疫学和病毒学、巨噬细胞生物学和免疫学以及 HIV/SIV 感染动物模型领域的专家，讨论了巨噬细胞作为生理相关病毒库的作用，以及巨噬细胞感染对人类健康的影响。 HIV 发病机制和治疗策略。尽管仍有争议，但有一种新兴理论认为，受感染的巨噬细胞可能在联合抗逆转录病毒治疗中持续存在。然后，这些巨噬细胞可以驱动持续的炎症并促进病毒储存，这表明在未来的治疗策略中解决巨噬细胞以及 CD4+ T 细胞的重要性。
Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection, accumulating evidence suggests that macrophages also contribute. However, investigations of the role of macrophages are often underrepresented at HIV pathogenesis and cure meetings. This was the impetus for a scientific workshop dedicated to this area of study, held in Cambridge, MA in January 2017. The workshop brought together experts in the fields of HIV/SIV immunology and virology, macrophage biology and immunology, and animal models of HIV/SIV infection to discuss the role of macrophages as a physiologically relevant viral reservoir, and the implications of macrophage infection for HIV pathogenesis and strategies for cure. While still controversial, there is an emerging theory that infected macrophages likely persist in the setting of combination antiretroviral therapy. These macrophages could then drive persistent inflammation and contribute to the viral reservoir, which indicates the importance of addressing macrophages as well as CD4+ T cells with future therapeutic strategies.