Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality
Association of job stress,CLOCKgene polymorphism and their interaction with poor sleep quality
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工作压力、CLOCK基因多态性及其与睡眠质量差的交互作用
DOI：
10.1111/jsr.13133
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发表时间：
2020-07-07
影响因子：
4.4
通讯作者：
Zhang, Xiangyang
中科院分区：
文献类型：
--
作者：
Li, Yuling;Cao, Zeyuan;Zhang, Xiangyang
工作压力和昼夜节律运动输出周期Kaput（CLOCK）基因可以影响昼夜节律和睡眠质量。本研究的主要目的是探讨工作压力、CLOCK基因多态性及其与睡眠质量的关系。采用横断面设计，在北京招募了450名受试者。采用匹兹堡睡眠质量指数（PSQI）测量睡眠质量，采用工作压力量表测量工作压力。相关分析表明，高工作压力与PSQI及其各组成部分之间存在密切但不同的联系。方差分析显示，CLOCK基因rs 11932595多态性的主效应显著。G等位基因携带者在PSQI、睡眠持续时间、睡眠潜伏期和睡眠障碍方面得分较高。进一步的相互作用分析显示，有序的睡眠时间的相互作用，和日间功能障碍的无序的相互作用。具体而言，G等位基因携带者在高工作压力下的睡眠时间比AA纯合子差，而两个亚组在低工作压力下的睡眠时间相似，符合素质-压力模型。与G等位基因携带者相比，AA纯合子在低工作压力下经历较少的日间功能障碍，而在高工作压力下经历较多的日间功能障碍，符合差异易感性模型。由于遗传联系已被揭示，我们的调查可能有助于阐明睡眠质量的病因因素和实施干预措施以获得良好睡眠质量的目标。
Job stress and the Circadian Locomotor Output Cycles Kaput (CLOCK) gene could affect circadian rhythm and sleep quality. The main aim of our present study was to investigate the association of job stress,CLOCKgene polymorphism and their interaction with sleep quality in a non-clinical Chinese Han population, which has not been reported to date. Using a cross-sectional design, 450 subjects were recruited in Beijing. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and job stress was measured with the Work Stress Scale.CLOCKgene rs11932595 polymorphism was genotyped in 297 blood samples. Correlation analysis showed a close but different association of high job stress with the PSQI and its components. Analysis of variance showed significant main effects of theCLOCKgene rs11932595 polymorphism. G-allele carriers had a higher score in the PSQI, sleep duration, sleep latency and sleep disturbances. Further interaction analyses showed an ordinal interaction on sleep duration, and a disordinal interaction on daytime dysfunction. Specifically, G-allele carriers had poorer sleep duration than AA homozygotes when in high job stress, while the two subgroups displayed similar sleep duration when in low job stress, conforming to the diathesis-stress model. In comparison to G-allele carriers, AA homozygotes experienced less daytime dysfunction when in low job stress whereas more daytime dysfunction when in high job stress, fitting with the differential susceptibility model. As genetic links have been revealed, our investigation might be conducive for elucidating aetiological factors for sleep quality and targets for implementing interventions to attain good sleep quality.