The Impact of Stimulus Valence and Emotion Regulation on Sustained Brain Activation: Task-Rest Switching in Emotion
The Impact of Stimulus Valence and Emotion Regulation on Sustained Brain Activation: Task-Rest Switching in Emotion
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DOI：
10.1371/journal.pone.0093098
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发表时间：
2014-03-28
期刊：
影响因子：
3.7
通讯作者：
Walter, Henrik
中科院分区：
文献类型：
--
作者：
Lamke, Jan-Peter;Daniels, Judith K.;Walter, Henrik
任务-休息交互作用被定义为注视期间大脑激活的调节，取决于之前的刺激和实验操作，在大脑不同区域对不同认知要求的任务进行了反复描述。然而，情绪范式中的任务-休息交互作用受到的关注要少得多。因此，在本研究中，我们研究了由负面情绪的诱导和指导调节所引起的任务-休息交互作用。研究对象为55名健康受试者的全脑功能磁共振数据。计算了两个水平的一般线性模型统计量，以检验条件之间的差异，分别针对刺激和注视时期，以及刺激和注视之间的交互作用(任务-休息交互作用)。结果表明，负性情绪的调节导致杏仁核和视觉皮质区域的任务-休息交互作用逆转(刺激时激活减少，注视时激活增加)，而在背侧前额叶皮质以及默认模式和背侧注意网络交界处的一些大脑区域，导致协调的任务-休息交互作用(刺激和注视都增加)。因此，在负面情绪的诱导和调节之后，这项关于任务-休息相互作用的第一次全脑研究发现，大脑激活在从属于情绪产生和调节的区域以及与注意力和默认模式有关的区域中存在广泛的特定调制。
Task-rest interactions, defined as the modulation of brain activation during fixation periods depending on the preceding stimulation and experimental manipulation, have been described repeatedly for different cognitively demanding tasks in various regions across the brain. However, task-rest interactions in emotive paradigms have received considerably less attention. In this study, we therefore investigated task-rest interactions evoked by the induction and instructed regulation of negative emotion. Whole-brain, functional MRI data were acquired from 55 healthy participants. Two-level general linear model statistics were computed to test for differences between conditions, separately for stimulation and for fixation periods, as well as for interactions between stimulation and fixation (task-rest interactions). Results showed that the regulation of negative emotion led to reverse task-rest interactions (decreased activation during stimulation but increased activation during fixation) in the amygdala as well as in visual cortex regions and to concordant task-rest interactions (increased activation during both, stimulation and fixation) in the dorsolateral prefrontal cortex as well as in a number of brain regions at the intersection of the default mode and the dorsal attention networks. Thus, this first whole-brain investigation of task-rest interactions following the induction and regulation of negative emotion identified a widespread specific modulation of brain activation in regions subserving emotion generation and regulation as well as regions implicated in attention and default mode.