Effects of tropic hormones on ultrastructure and synthesis of androgens in adrenals of male pseudohermaphrodite rats
Effects of tropic hormones on ultrastructure and synthesis of androgens in adrenals of male pseudohermaphrodite rats
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热带激素对雄性假两性大鼠肾上腺超微结构及雄激素合成的影响
DOI：
10.1007/bf00209133
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发表时间：
1978
影响因子：
3.6
通讯作者：
K. Chung
中科院分区：
文献类型：
--
作者：
K. Chung
摘要：假性雌雄同体（tfm）大鼠肾上腺的超微结构和生化研究显示肾上腺皮质细胞肥大。束状带和网状带细胞的细胞质包含一个非常发达的光滑内质网，与线粒体和脂滴紧密相连。线粒体数量比正常细胞多，管状嵴特别丰富。更多的脂滴（表现为空液泡）被多形性线粒体包围。实验结果表明，tfm大鼠肾上腺皮质分泌雄激素的能力明显高于正常动物。垂体切除术和去势导致tfm大鼠肾上腺雄激素生物合成显著减少，并导致血浆睾酮浓度降低。给去垂体的阉割大鼠注射热带激素似乎能刺激它们的肾上腺雄激素生成。提示在tfm大鼠中，高于正常水平的促黄体生成素（LH）和促肾上腺皮质激素（ACTH）一起刺激肾上腺皮质细胞器的肥大，并导致雄激素类固醇的增加，这可能是导致血浆雄激素水平升高的部分原因。
SummaryUltrastructural and biochemical study of the adrenals in the pseudohermaphrodite (tfm) rat reveals hypertrophic adrenocortical cells. The cytoplasm of the cells in the zonae fasciculata and reticularis contains an exceptionally well developed smooth endoplasmic reticulum closely applied to mitochondria and lipid droplets. Mitochondria are more numerous than in normals and have especially abundant tubular cristae. More lipid droplets (appearing as empty vacuoles) are surrounded by pleomorphic mitochondria.The incubation study indicates that the capacity of rat adrenal cortex of producing androgens is greater in tfm than in normal animals. Hypophysectomy and castration result in a significant decrease in androgen biosynthesis by tfm rat adrenals and cause a reduced concentration of plasma testosterone. Administration of tropic hormones to hypophysectomizedcastrated rats appears to stimulate their adrenal androgenesis. It is suggested that in tfm rats the higher than normal luteinizing hormone (LH) together with adrenocorticotropic hormone (ACTH) stimulates the hypertrophy of cellular organelles in the adrenal cortex and causes an accompanying increase in androgenic steroids which may be responsible, at least in part, for the increased level of plasma androgens.