Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography
Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography
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DOI：
10.1038/lsa.2014.18
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发表时间：
2014-01-01
影响因子：
19.4
通讯作者：
Razansky, Daniel
中科院分区：
文献类型：
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作者：
Dean-Ben, Xose Luis;Razansky, Daniel
光声学为生物成像提供了一套独特的功能，与超声波和光相关优势的内在结合相关，例如高空间和时间分辨率以及生物组织中强大的光谱丰富的成像对比度。我们在这里首次展示了五维光声数据的采集、处理和可视化，从而提供了当前生物成像模式中无与伦比的成像能力。新发现的性能是通过同时体积检测和多光谱数据处理实现的，并通过获得人体深层血管中的时间分辨体积血氧图和实时跟踪小鼠模型体内造影剂分布来进一步展示。
Optoacoustics provides a unique set of capabilities for bioimaging, associated with the intrinsic combination of ultrasound-and light-related advantages, such as high spatial and temporal resolution as well as powerful spectrally enriched imaging contrast in biological tissues. We demonstrate here, for the first time, the acquisition, processing and visualization of five-dimensional optoacoustic data, thus offering unparallel imaging capacities among the current bioimaging modalities. The newly discovered performance is enabled by simultaneous volumetric detection and processing of multispectral data and is further showcased here by attaining time-resolved volumetric blood oxygenation maps in deep human vessels and real-time tracking of contrast agent distribution in a murine model in vivo.