Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study
Clinical characteristics of 276 hospitalized patients with coronavirus disease 2019 in Zengdu District, Hubei Province: a single-center descriptive study
复制标题
湖北省曾都区276例2019年冠状病毒病住院患者临床特征：单中心描述性研究
DOI：
10.1186/s12879-020-05252-8
复制
发表时间：
2020-07-29
影响因子：
3.7
通讯作者：
Liu, Jiansheng
中科院分区：
文献类型：
--
作者：
Wei, Yiping;Zeng, Weibiao;Liu, Jiansheng
背景：报道湖北省增都区新冠肺炎住院患者的流行病学和临床特征。方法：收集2020年1月27日至3月11日增都医院住院患者的临床资料，该医院是武汉周边地区一家由志愿医生支持的社区医院。所有新冠肺炎住院患者均纳入本研究。分析这些患者的流行病学表现、临床特征、实验室检查结果、放射学表现和临床转归。对这些患者的临床结果进行了随访，直到2020年3月22日。重症新冠肺炎病例包括根据第七版中国新冠肺炎诊断指南诊断的重症和危重病例。结果：纳入住院的新冠肺炎患者276例，中位年龄51.0岁，其中非重症患者262例，重症患者14例。重度组60岁以上老年患者比例(78.6%)高于非重度组(18.7%，P<；0.01)。大约四分之一的患者(24.6%)至少有一种共病，如高血压、糖尿病或癌症，重症组患者合并疾病的比例(85.7%)高于非重症组(21.4%，p<；0.01)。常见症状为发热(82.2%[227/276])和咳嗽(78.0%[218/276])。38.4%(106/276)的患者入院时有发热症状。大多数患者(94.9%[204/276])治愈出院，3.6%(10/276)病情恶化转院。中位新冠肺炎治疗时间和住院天数分别为14.0天和18.0天。结论：增都地区新冠肺炎患者多为轻度疾病。患有基础疾病的老年患者进展为严重疾病的风险更高。新冠肺炎的住院天数和抗病毒治疗天数略长于武汉。这项工作有助于了解新冠肺炎核心暴发区周边地区的特点，为类似地区的疫情防控决策提供参考。
Background: We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China.Methods: Clinical data on COVID-19 inpatients in Zengdu Hospital from January 27 to March 11, 2020 were collected; this is a community hospital in an area surrounding Wuhan and supported by volunteer doctors. All hospitalized patients with COVID-19 were included in this study. The epidemiological findings, clinical features, laboratory findings, radiologic manifestations, and clinical outcomes of these patients were analyzed. The patients were followed up for clinical outcomes until March 22, 2020. Severe COVID-19 cases include severe and critical cases diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines. Severe and critical COVID-19 cases were diagnosed according to the seventh edition of China's COVID-19 diagnostic guidelines.Results: All hospitalized COVID-19 patients, 276 (median age: 51.0 years), were enrolled, including 262 non-severe and 14 severe patients. The proportion of patients aged over 60 years was higher in the severe group (78.6%) than in the non-severe group (18.7%, p < 0.01). Approximately a quarter of the patients (24.6%) had at least one comorbidity, such as hypertension, diabetes, or cancer, and the proportion of patients with comorbidities was higher in the severe group (85.7%) than in the non-severe group (21.4%, p < 0.01). Common symptoms included fever (82.2% [227/276]) and cough (78.0% [218/276]). 38.4% (106/276) of the patients had a fever at the time of admission. Most patients (94.9% [204/276]) were cured and discharged; 3.6% (10/276) deteriorated to a critical condition and were transferred to another hospital. The median COVID-19 treatment duration and hospital stay were 14.0 and 18.0 days, respectively.Conclusions: Most of the COVID-19 patients in Zengdu had mild disease. Older patients with underlying diseases were at a higher risk of progression to severe disease. The length of hospital-stay and antiviral treatment duration for COVID-19 were slightly longer than those in Wuhan. This work will contribute toward an understanding of COVID-19 characteristics in the areas around the core COVID-19 outbreak region and serve as a reference for decision-making for epidemic prevention and control in similar areas.