Research Letter: Impact of Obstructive Sleep Apnea Disease Duration on Neuropsychological Functioning After Traumatic Brain Injury: A Veterans Affairs TBI Model Systems Study.
Research Letter: Impact of Obstructive Sleep Apnea Disease Duration on Neuropsychological Functioning After Traumatic Brain Injury: A Veterans Affairs TBI Model Systems Study.
复制标题
DOI：
10.1097/htr.0000000000000797
复制
发表时间：
2022-11-01
影响因子：
2.4
通讯作者：
Nakase-Richardson, Risa
中科院分区：
文献类型：
--
作者：
Silva, Marc A.;Lee, Jaylene M.;Garcia, Amanda;Dams-O'Connor, Kristen;Nakase-Richardson, Risa
关键词：
研究有创伤性脑损伤 (TBI) 病史的阻塞性睡眠呼吸暂停 (OSA) 病程与认知功能之间的关系。我们假设 OSA 持续时间越长，认知能力就越差。退伍军人事务部 (VA) 多发伤康复中心的脑损伤住院病房。参与者。 VA TBI 模型系统多中心纵向研究的参与者参加了一项模块化子研究（2018 年 4 月 15 日至 2021 年 1 月 15 日），检查 TBI 后的认知能力。所有参与者都接受过 TBI 住院康复治疗，并报告诊断为 OSA（n = 89，年龄 M = 40.8 岁，97% 男性，81% 白人）。报告的 OSA 持续时间为 2 至 7 年（M = 4.2；SD = 3.9）。前瞻性队列的回顾性分析，横断面。成人电话认知简短测试 (BTACT)。控制年龄、教育程度和遵循命令的时间后，OSA 疾病持续时间与言语记忆延迟呈负相关 [R2Δ = .053，F(1,84) = 5.479，p = .022]。其他认知领域的表现与 OSA 疾病持续时间没有显着相关。这项研究提供了初步证据，表明较长的 OSA 持续时间（即诊断后的时间）对有住院 TBI 病史的患者的言语记忆有负面影响。这一发现扩展了有关 OSA 对认知影响的文献（主要针对普通人群），并且与海马损伤和疲劳继发影响等假设机制一致。研究结果表明，早期 OSA 识别和治疗对于 TBI 患者可能是谨慎的。
To examine the relationship between Obstructive Sleep Apnea (OSA) disease duration and cognitive functioning in those with history of traumatic brain injury (TBI). We hypothesized that longer OSA duration would predict poorer cognitive performance. Inpatient brain injury units at a Veterans Affairs (VA) Polytrauma Rehabilitation Center. Participants. Participants in the VA TBI Model Systems multi-center longitudinal study who enrolled in a modular sub-study (4/15/2018 to 1/15/2021) examining cognition following TBI. All participants had received inpatient rehabilitation for TBI and reported a diagnosis of OSA (n = 89, age M = 40.8 years, 97% male, 81% White). Reported duration of OSA ranged from 2 to 7 years (M = 4.2; SD = 3.9). Retrospective analysis of prospective cohort, cross-sectional. Brief Test of Adult Cognition by Telephone (BTACT). Controlling for age, education, and time to follow commands, OSA disease duration was negatively associated with delayed verbal memory [R2Δ = .053, F(1,84) = 5.479, p = .022]. Performance in other cognitive domains was not significantly associated with OSA disease duration. This study provides preliminary evidence that longer duration of OSA (i.e., time since diagnosis) has a negative impact on verbal memory in those with history of hospitalized TBI. This finding extends the literature (which focused on the general population) on the cognitive impact of OSA and is consistent with hypothesized mechanisms such as hippocampal damage and secondary impact of fatigue. Findings suggest that early OSA identification and treatment may be prudent for persons with TBI.
影响因子：
4.2
作者：
Garcia A;Reljic T;Pogoda TK;Kenney K;Agyemang A;Troyanskaya M;Belanger HG;Wilde EA;Walker WC;Nakase-Richardson R
通讯作者：
Nakase-Richardson R