IL-17-producing γδ T cells enhance bone regeneration.
IL-17-producing γδ T cells enhance bone regeneration.
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产生 IL-17 的 γδ T 细胞可促进骨再生。
DOI：
10.1038/ncomms10928
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发表时间：
2016-03-11
影响因子：
16.6
通讯作者：
Takayanagi H
中科院分区：
文献类型：
--
作者：
Ono T;Okamoto K;Nakashima T;Nitta T;Hori S;Iwakura Y;Takayanagi H
免疫反应不仅对于宿主防御病原体至关重要，而且对于损伤后的组织维护和修复也至关重要。淋巴细胞参与组织损伤后的愈合过程，包括骨折和肌肉损伤。然而，特定的免疫细胞亚群和愈合介质尚不完全清楚。在这里，我们发现 γδ T 细胞产生 IL-17A，促进骨形成并促进骨折愈合。由于成骨细胞骨形成缺陷，IL-17A 缺陷小鼠的修复受损。 IL-17A 通过刺激间充质祖细胞的增殖和成骨细胞分化来加速骨形成。这项研究确定了产生 IL-17 的 γδ T 细胞在骨骼组织再生中的新作用。 γδ T 细胞是先天性淋巴细胞，通过产生 IL-17A 或 IFN-γ 来调节免疫反应，但在骨愈合中的作用尚不清楚。在这里，作者展示了小鼠中 Vγ6+ 亚群产生的 IL-17A 的非免疫骨再生功能。
Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration. γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.