NEUROLEPTIC TREATMENT OF SCHIZOTYPAL PERSONALITY-DISORDERS
NEUROLEPTIC TREATMENT OF SCHIZOTYPAL PERSONALITY-DISORDERS
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DOI：
10.1016/0010-440x(86)90001-5
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发表时间：
1986-07-01
影响因子：
7.3
通讯作者：
HOYT, R
中科院分区：
文献类型：
--
作者：
HYMOWITZ, P;FRANCES, A;HOYT, R
在一项单盲试验中，17名分裂型患者接受了小剂量氟哌啶醇治疗。注意到总体分裂类型症状的改善，如访谈边界线时间表(SIB)所评估的，积极的变化特别反映在衡量参照想法、奇怪沟通和社会隔离的量表上。全球评估量表(GAS)上的评级表明总体临床改善。对副作用，特别是镇静的抱怨是强烈的，并导致50%的辍学率。通过研究表明，小剂量氟哌啶醇可能对某些分裂型人格有用，它也强调了一组对副作用高度敏感的患者的严重依从性问题。
Seventeen schizotypal patients were treated with low doses of Haloperidol in a single-blind trial. Improvement was noted on overall schizotypal symptoms as assessed on the Schedule for Interviewing Borderlines (SIB) with positive change particularly reflected on the scales measuring Ideas of Reference, Odd Communication and Social Isolation. Ratings on the Global Assessment Scale (GAS) indicated overall clinical improvement. Complaints of side effects, particularly sedation were entensive and contributed to a 50% dropout rate. Through the study indicates that low dose Haloperidol may be useful for some schizotypal personalities, it also underscores the serious compliance problems in a group of patients highly sensitive to side effects.