Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs
Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs
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DOI：
10.1007/s40588-018-0101-2
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发表时间：
2018-07
影响因子：
5.2
通讯作者：
H. Katano
中科院分区：
文献类型：
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作者：
H. Katano
综述目的疱疹病毒是一种大的DNA病毒，其基因组中含有许多产生非编码RNA的基因，如小RNA和长非编码RNA。本文综述了卡波济肉瘤相关疱疹病毒（Kaposi's sarcoma-associated herpesvirus，KSHV）非编码RNA的表达和功能。多聚腺苷酸化核RNA是KSHV感染细胞中高度表达的病毒lncRNA分子，并且是KSHV复制所必需的。KSHV miRNAs主要在KSHV感染的潜伏期期间表达，不仅在细胞中，而且在细胞外囊泡如外来体和病毒体中。对病毒miRNA靶点的鉴定揭示了KSHV miRNA具有与肿瘤发生、抗凋亡、血管生成和KSHV感染细胞的迁移相关的多种功能。KSHV非编码RNA在KSHV相关疾病的发病机制中起重要作用。
Purpose of ReviewHerpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed.Recent FindingsThe KSHV genome contains at least 12 genes from which pre-microRNAs (miRNAs) are transcribed, and several genes producing long non-coding RNAs (lncRNAs). Polyadenylated nuclear RNA is a highly expressed viral lncRNA molecule in KSHV-infected cells and is necessary for KSHV replication. KSHV miRNAs are expressed predominantly during the latent phase of KSHV infection not only in cells but also in extracellular vesicles such as exosomes and virions. Identification of viral miRNA targets has revealed that KSHV miRNAs have various functions relating to oncogenesis, anti-apoptosis, angiogenesis, and migration of KSHV-infected cells. Some KSHV miRNAs regulate KSHV replication to maintain viral latency.SummaryKSHV non-coding RNAs play significant roles in the pathogenesis of KSHV-associated diseases.