The naked mole-rat? A new long-living model for human aging research
The naked mole-rat? A new long-living model for human aging research
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DOI：
10.1093/gerona/60.11.1369
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发表时间：
2005-11-01
影响因子：
5.1
通讯作者：
Buffenstein, R
中科院分区：
文献类型：
--
作者：
Buffenstein, R
实验操纵导致的寿命降低的物种黯然失色的最大寿命巨大变化。尽管这些物种可能暴露了抗老化的机制，但很少有衰老研究集中于长寿命的哺乳动物。裸mole鼠（与35克相似）是已知最长的（> 28。3年）的啮齿动物。这篇评论描述了他们在衰老研究中的生物学和潜在用途。生活方式与大多数进化论的理论一致，除了一次性的索马理论。实际上，在育种者和非繁殖者中，最大寿命相似，这些高度粪便的动物繁殖直到死亡。具有延长寿命的小鼠模型的限制性，蛋氨酸限制性和矮小的小鼠的共同特征包括体温降低；甲状腺降低和血糖浓度；和低糖化的血红蛋白；除了癌症发病率降低。年轻的裸鼠鼠出人意料地具有高水平的应计氧化损伤。这些啮齿动物凭借对人类的寿命相似，可以提供一个新的机会来检查调节衰老的机制。
Tremendous variation in maximum life span among species overshadows modest increases in longevity resulting from experimental manipulation. Few aging studies focus on long-lived mammals even though these species may expose mechanisms involved in resisting aging. Naked mole-rats (NMRs similar to 35 grams) are the longest-living (>28.3 years) rodents known. This review describes their biology and potential use in aging research. Lifestyle features concur with most evolutionary theories with the exception of the disposable soma theory. Indeed, maximum life span is similar in breeders and nonbreeders, and these highly fecund animals reproduce until they die. Shared characteristics with calorie-restricted, methionine-restricted, and dwarf mice models of extended longevity include reduced body temperature; reduced thyroid, and blood glucose concentrations; and low glycated hemoglobin; in addition to reduced incidence of cancer. Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging.