HAART induces the expression of HLA-G on peripheral monocytes in HIV-1 infected individuals
HAART induces the expression of HLA-G on peripheral monocytes in HIV-1 infected individuals
复制标题
DOI：
10.1016/j.humimm.2003.08.353
复制
发表时间：
2003-11-01
期刊：
影响因子：
2.7
通讯作者：
Peña, J
中科院分区：
文献类型：
--
作者：
Cabello, A;Rivero, A;Peña, J
这项工作的目的是分析如果高效抗逆转录病毒治疗（HAART）有任何影响的外周血单核细胞表达的耐受性分子人类白细胞抗原G（HLA-G）在HIV-1感染者的数量。在这个意义上，HLA-G的表达通过流式细胞术测量外周单核细胞从HIV-1抗逆转录病毒接受和抗逆转录病毒初治患者和HIV-1患者在不同时间后的抗逆转录病毒治疗被删除。在接受HAART的HIV-1感染者中，发现表达HLA-G的单核细胞增加，而来自未经治疗的HIV-1患者的单核细胞没有变化。当在去除抗逆转录病毒治疗后在单核细胞上测量HLA-G时，表达HLA-G的外周单核细胞的数量逐渐减少。这些数据表明，抗逆转录病毒治疗能够诱导耐受性分子HLA-G对外周血单核细胞从HIV-1血清阳性个体的表达。Human Immunology 64，1045-1049（2003）. (C)美国组织相容性和免疫遗传学学会，2003年。爱思唯尔公司出版
The aim of this work is to analyze if the highly active antiretroviral therapy (HAART) has any effect in the number of peripheral monocytes expressing the tolerogenic molecule human leukocyte antigen G (HLA-G) in HIV-1 infected individuals. In this sense, expression of HLA-G was measured by flow cytometry on peripheral monocytes from HIV-1 antiretroviral-receiving and antiretroviral naive patients and in HIV-1 patients at different times after the antiretroviral treatments were removed. It was found an increment of monocytes expressing HLA-G in HIV-1 infected individuals receiving HAART, whereas monocytes from untreated HIV-1 patients did not change. When the HLA-G was measured on monocytes after antiretroviral treatment was removed, the number of peripheral monocytes expressing HLA-G was progressively decreasing. These data suggest that antiretroviral therapy is able to induce the expression of the tolerogenic molecule HLA-G on peripheral monocytes from HIV-1 seropositive individuals. Human Immunology 64, 1045-1049 (2003). (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.