Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
复制标题
步态相位调节脚桥核中的α和β振荡
DOI：
10.1101/2021.03.05.434086
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
He S
中科院分区：
文献类型：
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作者：
He S
脚桥核（pedunculopontine nucleus，PPN）是位于中脑和脑桥交界处的网状神经元集合，在调节姿势和运动中起重要作用。PPN的深部脑刺激已被提议作为帕金森病（PD）或多系统萎缩（MSA）患者的一种新兴治疗方法，这些患者患有步态相关的非典型帕金森综合征。在这项研究中，我们研究了PPN活动在步态中，以更好地了解其在运动中的功能作用。具体来说，我们研究了PPN活动是否有节奏地调制的步态周期在运动。记录PD或MSA患者在原地踏步或自由行走时步态困难的PPN局部场电位（LFP）活动。使用测力板或加速度计的同时测量来确定每个时间点的每个步态周期内的相位。我们的研究结果表明，在α和β频段的PPN LFPs的活动有节奏地调制的步态周期内的步态相位，具有较高的调制指数时，步进节奏更规则。同时，PPN-皮层相干性在α波段最为突出。α/β功率中的步态相位相关调制和α频带中的PPN-皮质相干性都是PPN的空间特定性，并且不会延伸到周围区域。这些结果表明，交替PPN调制可以支持步态控制。通过交替方式刺激来增强交替PPN调制是否会积极影响步态控制仍有待测试。显著性声明脚桥核（PPN）脑深部电刺激（DBS）的治疗效果及其在多大程度上可以改善生活质量仍不确定。了解PPN活动是如何通过步进或步行调节的，可以深入了解如何提高PPN DBS改善步态困难的疗效。我们的研究表明，PPN α和β活性受到步态相位的调制，并且当步进节奏规则时，这一点最为明显。通过以交替方式刺激来增强交替PPN调制是否会对步态控制产生积极影响仍有待检验。
The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an emerging treatment for patients with Parkinson's disease (PD) or multiple system atrophy (MSA) who have gait-related atypical parkinsonian syndromes. In this study, we investigated PPN activities during gait to better understand its functional role in locomotion. Specifically, we investigated whether PPN activity is rhythmically modulated by gait cycles during locomotion. PPN local field potential (LFP) activities were recorded from PD or MSA patients with gait difficulties during stepping in place or free walking. Simultaneous measurements from force plates or accelerometers were used to determine the phase within each gait cycle at each time point. Our results showed that activities in the alpha and beta frequency bands in the PPN LFPs were rhythmically modulated by the gait phase within gait cycles, with a higher modulation index when the stepping rhythm was more regular. Meanwhile, the PPN–cortical coherence was most prominent in the alpha band. Both gait phase-related modulation in the alpha/beta power and the PPN–cortical coherence in the alpha frequency band were spatially specific to the PPN and did not extend to surrounding regions. These results suggest that alternating PPN modulation may support gait control. Whether enhancing alternating PPN modulation by stimulating in an alternating fashion could positively affect gait control remains to be tested.SIGNIFICANCE STATEMENTThe therapeutic efficacy of pedunculopontine nucleus (PPN) deep brain stimulation (DBS) and the extent to which it can improve quality of life are still inconclusive. Understanding how PPN activity is modulated by stepping or walking may offer insight into how to improve the efficacy of PPN DBS in ameliorating gait difficulties. Our study shows that PPN alpha and beta activity was modulated by the gait phase, and that this was most pronounced when the stepping rhythm was regular. It remains to be tested whether enhancing alternating PPN modulation by stimulating in an alternating fashion could positively affect gait control.