Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings
Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings
复制标题
Macropodumine A 的结构修正和 2-Deoxymacropodumine A 的结构，具有 11 元大环内酯环的瑞香生物碱
DOI：
10.1021/acs.jnatprod.8b00232
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发表时间：
2019
影响因子：
5.1
通讯作者：
Hao Xiaojiang
中科院分区：
文献类型：
--
作者：
Zhang Jiahui;Cao Pei;Ma Yuanliang;Fang Xin;Yang Jing;Zhang Yu;Chen Duozhi;Gu Yucheng;Di Yingtong;Hao Xiaojiang
从水蚤茎的提取物中获得了一种不寻常的水蚤类生物碱，2-脱氧水蚤碱A(1)，具有11元的大内酯环。通过一维和二维核磁共振波谱方法和化学计算对其结构进行了分析。在实验数据与核磁共振计算数据对比的基础上，对1的类似物大莨菪碱a（2′）的结构进行了修正。
An unusualDaphniphyllumalkaloid, 2-deoxymacropodumine A (1), possessing an 11-membered macrolactone ring, was obtained from an extract of the stems ofDaphniphyllum angustifolium. The structure of1was elucidated by 1D and 2D NMR spectroscopic methods and chemical calculations. Based on a comparison of the experimental and calculated NMR data, the structure of macropodumine A (2′), an analogue of1, was also revised.