Temperament and adolescent substance use: an epigenetic approach to risk and protection.
Temperament and adolescent substance use: an epigenetic approach to risk and protection.
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DOI：
10.1111/1467-6494.00129
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发表时间：
2000-12
影响因子：
5
通讯作者：
T. Wills;J. Sandy;Alison M. Yaeger
中科院分区：
文献类型：
--
作者：
T. Wills;J. Sandy;Alison M. Yaeger
我们概述了一种表观遗传学方法，用于理解简单的气质特征与复杂的问题行为之间的关系，重点关注青少年的物质使用情况。表观遗传学理论预测，气质的影响是通过自我控制和冒险倾向来介导的，这些同构属性基于气质，但代表了这些特征的发展演变。我们描述了该研究项目如何证实了表观遗传学理论的预测，解决了该理论中包含的其他问题，并阐明了从气质特征到生活压力、社会关系以及物质使用动机的多种途径。在最后一部分，我们讨论了对问题行为和精神病理学研究的启示。
We outline an epigenetic approach to understanding the relation between simple dispositional characteristics and complex problem behaviors, with a focus on adolescent substance use. Epigenetic theory predicts that effects of temperament are mediated through self-control and risk-taking tendency, isomorphic attributes that are based in temperament but represent developmental elaborations of these characteristics. We describe how the research program has confirmed predictions from epigenetic theory, addressed additional questions embodied in the theory, and clarified the multiple pathways from temperament characteristics to life stress, social relationships, and motives for substance use. In a final section, we discuss implications for the study of problem behavior and psychopathology.