Histone modifications in transcriptional regulation
Histone modifications in transcriptional regulation
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DOI：
10.1016/s0959-437x(02)00279-4
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发表时间：
2002-04-01
影响因子：
4
通讯作者：
Berger, SL
中科院分区：
文献类型：
--
作者：
Berger, SL
核小体中核心历史氨基酸末端的共价修饰在基因调控中具有重要作用。过去两年的研究表明，这些修饰除了更好地表征乙酰化外，还包括磷酸化、甲基化和泛素化。这种修饰的多样性，以及它们在模式和依赖序列中的出现，令人信服地证明了组蛋白密码的存在。
Covalent modifications of the amino termini of the core histories in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.