Prevalence of iron deficiency and anemia among healthy women of reproductive age in Bhaktapur, Nepal
Prevalence of iron deficiency and anemia among healthy women of reproductive age in Bhaktapur, Nepal
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DOI：
10.1038/sj.ejcn.1602508
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发表时间：
2007-02-01
影响因子：
4.7
通讯作者：
Sommerfelt, H.
中科院分区：
文献类型：
--
作者：
Chandyo, R. K.;Strand, T. A.;Sommerfelt, H.
目的：为了确定贫血和铁状态的患病率评估的生化标志物，并探讨标志物的铁状态和铁intake.Study area和人口之间的关联：五百健康的育龄妇女从Bhaktapur区的Nepal.Methods：一个整群抽样程序被应用于本横断面研究。从人群中随机选择年龄在13-35岁之间的无任何持续感染的妇女。我们测定了血红蛋白（Hb）、铁蛋白和转铁蛋白受体的血浆浓度。膳食信息通过食物频率问卷和两次24小时膳食回忆获得。结果：贫血（Hb浓度< 12 g/dl）的患病率为12%（n = 58）。铁储备不足（血浆铁蛋白< 15 mg/l）的患病率为20%（n 98），而缺铁性贫血（贫血，铁储备不足，转铁蛋白受体升高，即> 1.54 mg/l）的患病率为6%（n 30）。百分之七（n 35）的妇女有铁缺乏性红细胞生成（耗尽铁储存和升高转铁蛋白受体，但正常血红蛋白）。在58名贫血妇女中，分别有41名（71%）和31名（53%）血浆转铁蛋白受体升高和铁储备减少。54%的女性摄入的铁低于推荐的平均摄入量。膳食铁的主要食物是大米，小麦粉和绿色和干蔬菜。结论：在我们的研究中贫血的患病率大大低于全国数字为非孕妇。只有大约一半的贫血妇女也有耗尽的铁储存，这表明贫血的其他原因可能在这一人群中普遍存在。
Objective: To determine the prevalence of anemia and iron status as assessed by biochemical markers and to explore the associations between markers of iron status and iron intake.Study area and population: Five hundred healthy women of reproductive age from the Bhaktapur district of Nepal were included in the study.Methods: A cluster sampling procedure was applied for this cross-sectional study. Women without any ongoing infection aged 13-35 years were selected randomly from the population. We measured the plasma concentration of hemoglobin (Hb), ferritin and transferrin receptors. Dietary information was obtained by a food frequency questionnaire and two 24-h dietary recalls.Results: The prevalence of anemia ( Hb concentration < 12 g/dl) was 12% (n = 58). The prevalence of depleted iron stores ( plasma ferritin < 15 mg/l) was 20% ( n 98) whereas the prevalence of iron deficiency anemia ( anemia, depleted iron stores with elevated transferrin receptor i.e. > 1.54 mg/l) was 6% ( n 30). Seven percent ( n 35) of women were having iron-deficient erythropoiesis ( depleted iron stores and elevated transferrin receptor but normal Hb). Out of the 58 anemic women, 41 (71%) and 31 (53%) were also having elevated plasma transferrin receptor and depleted iron stores, respectively. Fifty-four percent of the women ate less than the recommended average intake of iron. The main foods contributing to dietary iron were rice, wheat flour and green and dry vegetables.Conclusions: The prevalence of anemia in our study was substantially lower than the national figure for non-pregnant women. Only about half of the women with anemia were also having depleted iron stores, suggesting that other causes of anemia may be prevalent in this population.