Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients
Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients
复制标题
DOI：
10.1016/s0167-8140(02)00136-6
复制
发表时间：
2002-08-01
影响因子：
5.7
通讯作者：
Suma, S
中科院分区：
文献类型：
--
作者：
Koc, M;Polat, P;Suma, S
背景与目的：本研究旨在探讨乳腺癌患者经钴-60(Co-60)照射后，随着年龄的增长，三苯氧胺()是否会导致胸壁和区域淋巴管的肺纤维化。更年期状态。体重。材料与方法：本前瞻性研究采用轴位CT对74例乳腺癌术后辅助放射治疗(RT)患者和37例单纯放疗的患者(组)和37例单纯放疗组(对照组)进行对比研究。在开始放疗和治疗前首先进行CT检查。一位放射科医生对824个胸部CT切片进行了盲法评价。结果：74例单纯放疗和联合治疗的患者中26例出现肺纤维化，37例单纯放疗的患者中有5例出现肺纤维化。经统计学处理，差异有统计学意义(P
Background and purpose: This study was performed to investigate whether the tamoxifen (TAM) induced the development of pulmonary fibrosis after post-mastectomy cobalt-60 (Co-60) irradiation of chest wall and regional lymphatics in patients with breast cancer along with patient age. menopausal status. body weight. observation time and adjuvant chemotherapy regimens.Materials and methods: In this prospective study, 74 patients treated with post-mastectomy adjuvant radiotherapy (RT) and TAM and 37 patients treated with RT were evaluated by axial computerized tomography (CT). CT was first performed before initiation of radiotherapy and TAM treatment. A total of 824 thorax CT sections were evaluated by a,radiologist blindly. Comparison of pre-treatment and posttreatment CT sections was used to monitor the development of pulmonary fibrosis.Results: Pulmonary fibrosis developed in 26 of 74 patients who were treated with RT and TAM combination, It was found in five of 37 women treated only with RT. The difference was statistically significant (P