Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
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DOI：
10.1016/j.cub.2019.04.070
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发表时间：
2019-06-17
期刊：
影响因子：
9.2
通讯作者：
Papaleo, Francesco
中科院分区：
文献类型：
--
作者：
Ferretti, Valentina;Maltese, Federica;Papaleo, Francesco
对他人情绪的识别会影响社会性动物互动和适应环境的方式。神经肽催产素（OXT）与情绪处理的不同方面有关。然而，内源性 OXT 大脑通路在同种人不同情绪状态的社会反应中的作用仍然难以捉摸。在这里，我们结合解剖学、遗传学和化学遗传学方法，研究了内源性 OXT 信号传导对小鼠根据情绪状态区分不熟悉的同种动物的能力的贡献。我们发现从下丘脑室旁核 (PVN) 到中央杏仁核 (CeA) 的 OXTergic 投射对于区分正价和负价情绪状态至关重要。相反，阻断 PVN OXT 释放到伏核、前额皮质和海马 CA2 并没有改变这种情绪辨别能力。此外，沉默这些 PVN OXT 通路并不影响基本的社交互动。这些发现得到了进一步支持，即病毒介导的 CeA 内 OXT 信号传导的增强足以挽救认知责任遗传小鼠模型中的情绪辨别缺陷。我们的结果表明，CeA OXT 信号在生理和病理条件下的情绪辨别中发挥着关键作用。
Recognition of other's emotions influences the way social animals interact and adapt to the environment. The neuropeptide oxytocin (OXT) has been implicated in different aspects of emotion processing. However, the role of endogenous OXT brain pathways in the social response to different emotional states in conspecifics remains elusive. Here, using a combination of anatomical, genetic, and chemogenetic approaches, we investigated the contribution of endogenous OXT signaling in the ability of mice to discriminate unfamiliar conspecifics based on their emotional states. We found that OXTergic projections from the paraventricular nucleus of the hypothalamus (PVN) to the central amygdala (CeA) are crucial for the discrimination of both positively and negatively valenced emotional states. In contrast, blocking PVN OXT release into the nucleus accum bens, prefrontal cortex, and hippo-campal CA2 did not alter this emotion discrimination. Furthermore, silencing each of these PVN OXT pathways did not influence basic social interaction. These findings were further supported by the demonstration that virally mediated enhancement of OXT signaling within the CeA was sufficient to rescue emotion discrimination deficits in a genetic mouse model of cognitive liability. Our results indicate that CeA OXT signaling plays a key role in emotion discrimination both in physiological and pathological conditions.