Acute effect of nicotine on auditory gating in smokers and non-smokers
Acute effect of nicotine on auditory gating in smokers and non-smokers
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DOI：
10.1016/j.heares.2004.11.009
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发表时间：
2005-04-01
期刊：
影响因子：
2.8
通讯作者：
Hedrick, MS
中科院分区：
文献类型：
--
作者：
Harkrider, AW;Hedrick, MS
本文通过评估尼古丁（一种乙酰胆碱模拟药物）对安静和宽带噪声（BBN）中辅音-元音（CV）辨别的行为和电生理测量的急性影响，研究胆碱能机制在听觉门控中的作用。为了拟合单盲程序，我们从 10 名非吸烟者和 4 名听力正常的吸烟者在两种药物条件（尼古丁、安慰剂）下获得了两种条件（安静、BBN）下的分类边界和失配阴性（MMN）。尼古丁治疗结束后，血浆测试显示了受试者的尼古丁浓度，并且受试者报告了任何症状。较大的 MMN 面积和较陡的边界斜率分别被解释为反映了更好的电生理和行为 CV 辨别力。结果表明，在非吸烟者中，尼古丁对电生理CV辨别的影响随着症状严重程度的增加而增加。具体来说，无症状的非吸烟者 (N = 5) 的表现几乎没有改善（有时甚至有所下降），而有症状的非吸烟者 (N = 5) 则表现出尼古丁增强的歧视，吸烟者也是如此。在噪音中，所有受试者都表现出尼古丁增强的行为和电生理辨别力。此外，在噪音中，在安慰剂和尼古丁治疗中，吸烟者都比非吸烟者表现出更多的可测量分类边界以及更大的 MMN 区域。结果与烟碱胆碱能机制在听觉刺激的门控中发挥作用的假设一致。 (c) 2004 Elsevier B.V. 保留所有权利。
This paper investigates the role of cholinergic mechanisms in auditory gating by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on behavioral and electrophysiological measures of consonant-vowel (CV) discrimination in quiet and in broadband noise (BBN). fit a single-blind procedure, categorical boundaries and mismatch negativity (MMN) in two conditions (quiet, BBN) were obtained from 10 non-smokers and 4 smokers with normal hearing under two drug conditions (nicotine, placebo). After the nicotine sessions, plasma tests revealed a subject's nicotine concentration and subjects reported any symptoms. Larger MMN areas and steeper slopes at the boundary were interpreted as reflecting better electrophysiological and behavioral CV discrimination, respectively. Results indicate that, in non-smokers, the effects of nicotine on electrophysiological CV discrimination in quiet increase with an increase in severity of symptoms. Specifically, asymptomatic non-smokers (N = 5) demonstrate little improvement (and sometimes decrements) in performance while symptomatic non-smokers (N = 5) exhibit nicotine-enhanced discrimination, as do smokers. In noise, all subjects demonstrate nicotine-enhanced behavioral and electrophysiological discrimination. Additionally, in noise, smokers exhibit a larger number of measurable categorical boundaries as well as larger MMN areas than non-smokers in both placebo and nicotine sessions. Results are consistent with the hypothesis that nicotinic cholinergic mechanisms play a role in the gating of auditory stimuli. (c) 2004 Elsevier B.V. All rights reserved.