Effects of heavy endurance physical exercise on inflammatory markers in non-athletes
Effects of heavy endurance physical exercise on inflammatory markers in non-athletes
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DOI：
10.1016/j.atherosclerosis.2009.10.025
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发表时间：
2010-04-01
期刊：
影响因子：
5.3
通讯作者：
Boman, Kurt
中科院分区：
文献类型：
--
作者：
Andersson, Jonas;Jansson, Jan-Hakan;Boman, Kurt
目的：体育活动对心血管疾病有有益作用，但其机制尚不清楚。一种可能的途径是通过定期体育活动的抗炎作用。我们的主要目的是研究耐力体育锻炼对急性期和恢复期c反应蛋白（CRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子- α (TNF - α)的影响。其次，我们研究了饮食对这些炎症标志物的影响。方法：20名年龄在18-55岁的男性参加了为期14天的越野滑雪之旅。他们每天行走12-30公里，相当于大约10小时的剧烈运动。参与者被随机分配到一组饮食，其中30%或40%的能量来自脂肪。在第0周、第1周和第2周以及第6周和第8周的恢复期分析炎症变量。结果：CRP和TNF α在两周运动期间显著升高（1.4 ~ 5.0 mg/l, p = 0.00和6.8 ~ 8.4 pg/ml, p = 0.00）。与基线（中位1.4 mg/l）相比，恢复期间CRP水平显著降低（中位0.7 mg/l），且与代谢变量无关。研究期间IL-6水平无明显变化。在饮食组中，只有高脂肪组在恢复期间观察到显著的CRP变化。结论：CRP和TNF α明显升高，但在剧烈运动时反应不同，而IL-6似乎没有明显变化。饮食组之间在炎症变量方面没有发现显著差异。2009爱思唯尔爱尔兰有限公司版权所有。
Objectives: Physical activity has beneficial effects on cardiovascular disease but the mechanisms are still somewhat unclear. One possible pathway may be through the anti-inflammatory effects attributed to regular physical activity. Our primary aim was to study the effects of endurance physical exercise on C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF alpha) during the acute and recovery phases. Secondarily, we studied the impact of diet on these inflammatory markers.Methods: Twenty men, aged 18-55 years, participated in a 14 days cross-country skiing tour. They traveled 12-30 km per day corresponding to about 10 h of heavy physical activity. The participants were randomized to a diet with either 30 or 40% of energy derived from fat. Inflammatory variables were analysed at week 0, after 1 and 2 weeks and during the recovery phase at week 6 and 8.Results: CRP and TNF alpha increased significantly during the two weeks of exercise (1.4-5.0 mg/l, p = 0.00 and 6.8-8.4 pg/ml, p = 0.00). CRP levels were significantly lower during recovery (median 0.7 mg/l) compared to baseline (median 1.4 mg/l) and did not correlate to metabolic variables. There were no significant changes in IL-6 levels during the study period. For dietary groups significant CRP changes were observed only in the high fat group during recovery.Conclusions: CRP and TNF alpha increased significantly but reacted differently during heavy physical activity while there seemed to be no significant changes in IL-6. No significant differences regarding inflammatory variables were found between the dietary groups. (C) 2009 Elsevier Ireland Ltd. All rights reserved.