Utility of chemiluminescence (ViziLite™) in the detection of oral potentially malignant disorders and benign keratoses
Utility of chemiluminescence (ViziLite™) in the detection of oral potentially malignant disorders and benign keratoses
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DOI：
10.1111/j.1600-0714.2011.01048.x
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发表时间：
2011-08-01
影响因子：
3.3
通讯作者：
Warnakulasuriya, S.
中科院分区：
文献类型：
--
作者：
Awan, K. H.;Morgan, P. R.;Warnakulasuriya, S.
背景：口腔潜在恶性疾病(OPMD)被认为是口腔癌发生的先兆。OPMD的检测可以提供干预措施，可能会减少这些疾病向恶性肿瘤的演变。在口腔检查后，使用商业检测试剂盒ViziLite评估化学发光法检测OPMD的准确性。方法：共有126名患者入选伦敦国王医院和盖伊医院口腔内科诊所就诊的患者，其中男性70名，女性56名，平均年龄58.5±11.9岁，口腔白色、红色以及白色和红色混合斑块。61名患者目前吸烟者，28名戒烟者，92名酒精使用者。结果：临床诊断为口腔白斑/红斑70例，口腔扁平苔藓32例，慢性增生性念珠菌病9例，磨擦性角化病13例，口腔黏膜下纤维化2例。在126个病灶中，95个(75.4%)呈现醋酸化。当用ViziLite系统观察时，大多数口腔白斑都增强了病变的可见度和清晰度。活检后，44例口腔上皮异型增生(29例轻度，8例中度，7例重度)。化学发光检测OPMD的敏感性(Se)和特异性(SP)分别为77.3%和27.8%。结论：虽然ViziLite具有检测OPMD的能力，但不能准确地显示OPMD。该设备可用作一般口腔粘膜检查系统，特别是可以改善白斑的可视化。口腔病理医学杂志(2011)40：541-544
BACKGROUND: Oral potentially malignant disorders (OPMD) are known to precede the development of oral cancer. Detection of OPMD allows delivery of interventions that may reduce the evolution of these disorders to malignancy. Following oral examinations, the accuracy of detection of OPMD by chemiluminescence was evaluated using a commercially available detection kit - ViziLite. Data derived were compared in relation to conventional oral examination and surgical biopsy.METHODS: A total of 126 patients, 70 men and 56 women (mean age 58.5 +/- 11.9 years) attending Oral Medicine Clinics at King's and Guy's Hospitals, London, with oral white, red, and mixed white and red patches were enrolled. Sixty-one patients were current smokers, 28 were ex-smokers, while 92 were alcohol users. In a detailed investigation, these patients underwent ViziLite examination followed by surgical biopsy.RESULTS: Based on the clinical diagnosis, 70 patients had oral leukoplakia/erythroplakia, 32 had oral lichen planus, nine had chronic hyperplastic candidiasis, and rest had frictional keratosis (13) or oral submucous fibrosis (2). Of 126 lesions, 95 (75.4%) showed aceto-whitening. Most oral leukoplakias had enhanced visibility and sharpness of the lesion when viewed with the ViziLite system. Following biopsy, 44 had oral epithelial dysplasia (29 mild, eight moderate, and seven severe). The sensitivity (se) and specificity (sp) of chemiluminescence for the detection of a dysplastic lesion were 77.3% and 27.8%, respectively.CONCLUSION: While ViziLite has the ability to detect OPMD, it does not accurately delineate dysplastic lesions. The device can be used as a general oral mucosal examination system and may in particular improve the visualization of leukoplakias. J Oral Pathol Med (2011) 40: 541-544