CHARACTERIZATION OF A ZINC FINGER GENE DISRUPTED BY THE T(15,17) IN ACUTE PROMYELOCYTIC LEUKEMIA
CHARACTERIZATION OF A ZINC FINGER GENE DISRUPTED BY THE T(15,17) IN ACUTE PROMYELOCYTIC LEUKEMIA
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DOI：
10.1126/science.1720570
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发表时间：
1991-11-29
期刊：
影响因子：
56.9
通讯作者：
SOLOMON, E
中科院分区：
文献类型：
--
作者：
GODDARD, AD;BORROW, J;SOLOMON, E
与急性早幼粒细胞白血病相关的易位t（15;17）导致视黄酸受体α (RARA)基因与PML基因融合。PML的特征表明，它是一种推定的锌指蛋白和潜在的转录因子，通常表达，至少有三种主要的转录产物。PML断点聚集在可选剪接外显子两侧的两个区域。虽然易位的白血病细胞通常只表达一种融合产物，但PML/RARA（在15q+衍生染色体上）和RARA/PML（在17q-衍生染色体上）都被转录。
The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML/RARA (on the 15q+ derivative chromosome) and RARA/PML (on the 17q- derivative) are transcribed.