Differential effects of alcohol drinking pattern on liver enzymes in men and women.
Differential effects of alcohol drinking pattern on liver enzymes in men and women.
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DOI：
10.1097/01.alc.0000128229.23396.42
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发表时间：
2004-06
期刊：
影响因子：
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通讯作者：
S. Stranges;J. Freudenheim;P. Muti;E. Farinaro;M. Russell;T. Nochajski;M. Trevisan
中科院分区：
文献类型：
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作者：
S. Stranges;J. Freudenheim;P. Muti;E. Farinaro;M. Russell;T. Nochajski;M. Trevisan
背景越来越多的证据表明，饮酒模式可能对健康有很大的影响；然而，很少有研究关注饮酒模式与酒精性肝损害风险之间的关系。本研究旨在研究谷氨酰转氨酶(GGT)、天冬氨酸氨基转移酶和丙氨酸氨基转移酶与当前饮酒和饮酒模式的某些方面(例如，一周内饮酒频率和与食物消费的关系)之间的关系。方法随机抽取纽约州伊利县和尼亚加拉县的2943名年龄在35~80岁、无已知肝病的白人居民进行横断面分析。结果发现GGT与GGT的相关性最显著；在男女中，现饮酒者和既往饮酒者的平均水平显著高于终身戒酒者。在基于饮酒四分之一的分析中，只有前两个四分之一的参与者比终生戒酒者和其他四分之一的参与者表现出显著的酶活性升高。在饮酒模式方面，有证据表明与性别有关。在男性中，日常饮酒者的GGT水平最高，而在女性中，周末饮酒者的GGT水平最高。与喝酒精饮料的女性相比，饮酒而不吃东西的女性(而不是男性)表现出更高的GGT水平。结论除饮酒量外，饮酒方式还可影响肝功能，且饮酒方式对肝功能和潜在肝功能损害的影响存在性别差异。
BACKGROUND Increasing evidence suggests that drinking pattern may have powerful implications for health; however, very few studies have focused on the association between drinking pattern and risk of alcoholic liver damage. This study was aimed at examining the association of gamma-glutamyltransferase (GGT), aspartate aminotransferase, and alanine aminotransferase with current alcohol consumption and with some aspects of drinking pattern (e.g., drinking frequency during the week and in relation to food consumption). METHODS A cross-sectional analysis was conducted of a random sample of 2943 white residents of Erie and Niagara Counties in New York State who were 35 to 80 years of age and free from known hepatic disease. RESULTS The most significant associations were found for GGT; in both sexes, average levels were significantly higher in current and former drinkers compared with lifetime abstainers. In analyses based on quartiles of alcohol consumption, only participants in the two top quartiles showed significantly elevated enzymes compared with both lifetime abstainers and participants in other quartiles. For drinking pattern, there was evidence of sex-specific associations. In men, daily drinkers showed the highest levels of GGT, whereas in women, the highest level of GGT was observed in weekend drinkers. Women (but not men) who consumed alcohol without food exhibited higher levels of GGT compared with women who consumed alcoholic beverages in relation to food. CONCLUSIONS These findings support the hypothesis that, in addition to amount, drinking pattern may affect liver function and that differences exist between sexes with regard to the effect of drinking pattern on liver function and potential liver damage.