The biology of CSF-1 and its receptor.
The biology of CSF-1 and its receptor.
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DOI：
10.1007/978-3-642-77377-8_5
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发表时间：
1992
影响因子：
--
通讯作者：
P. Roth;E. Stanley
中科院分区：
文献类型：
--
作者：
P. Roth;E. Stanley
脊椎动物血细胞的不断更新依赖于骨髓中造血干细胞的增殖和分化（Harrisonet等，1988）。这些细胞又产生祖细胞，祖细胞致力于更有限的分化途径。这些祖细胞的存活、增殖和分化受殖民地刺激因子（CSF）调节，之所以这样命名是因为它们能够促进单个祖细胞体外增殖和分化为具有可辨别的分化细胞类型的宏观集落（PluznikandSachs 1965; Bradley和Metcalf 1966;Ichikawaet al. 1966）。这组造血生长因子包括白细胞介素-3（IL-3）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、粒细胞集落刺激因子（G-CSF）、白细胞介素-5（IL-5）和集落刺激因子-1（CSF-1）（综述见STANLEYandJUBINSKY 1984; METCALF 1986）。
The constant renewal of blood cells in vertebrate species depends on the proliferation and differentiation of hematopoietic stem cells in the bone marrow (Harrisonet al. 1988). These cells in turn give rise to progenitor cells which are committed to more restricted pathways of differentiation. The survival, proliferation, and differentiation of these progenitor cells are regulated by the colony stimulating factors (CSFs), so named because of their ability to promote the in vitro proliferation and differentiation of single progenitor cells into macroscopic colonies with discernible differentiated cell types (PluznikandSachs1965;BradleyandMetcalf1966;Ichikawaet al. 1966). This group of hematopoietic growth factors includes interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), interleukin-5 (IL-5), and colony stimulating factor-1 (CSF-1) (reviewed inSTANLEYandJUBINSKY1984;METCALF1986).