AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma
AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma
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DOI：
10.1016/j.bbrc.2017.03.075
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发表时间：
2017-04-29
影响因子：
3.1
通讯作者：
Zhan, Yinchu
中科院分区：
文献类型：
--
作者：
Chen, Chenlin;Song, Guangyuan;Zhan, Yinchu
AURKA（极光激酶A）已被证实是癌症发展中的致癌基因；然而，其在肝细胞癌（HCC）转移中的作用和潜在机制尚不清楚。在本研究中，我们发现AURKA在HCC组织中表达上调，并与病理分期和远处转移相关。进一步发现AURKA参与HCC放疗后肿瘤转移。而过表达AURKA通过PI3K/AKT通路诱导上皮-间质转化（EMT）和癌症干细胞（CSC）行为，沉默AURKA可抑制辐射增强的细胞侵袭性HCC。综上所述，我们的研究结果表明，AURKA通过促进EMT和CSC特性，促进了照射后残留HCC的转移，提示AURKA抑制剂在HCC患者放疗中的潜在临床应用。(C) 2017爱思唯尔公司版权所有。
AURKA (aurora kinase A) has been confirmed as an oncogene in cancer development; however, its role and underlying mechanisms in the metastasis of hepatocellular carcinoma (HCC) remain unknown. In this study, We found that AURKA was up-regulated in HCC tissues and correlated with pathological stage and distant metastasis. Further found that AURKA was involved in the cancer metastases after radiation in HCC. While overexpression of AURKA induced epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) behaviors though PI3K/AKT pathway, silencing AURKA suppressed radiation-enhanced cell invasiveness of HCC. Taken together, our results suggested that AURKA contributed in metastasis of irradiated residul HCC though facilitating EMT and CSC properties, suggesting the potential clinical application of AURKA inhibitors in radiotherapy for patients with HCC. (C) 2017 Elsevier Inc. All rights reserved.