The effects of aging on satellite cells in skeletal muscles of mice and rats
The effects of aging on satellite cells in skeletal muscles of mice and rats
复制标题
衰老对小鼠和大鼠骨骼肌卫星细胞的影响
作者：
M. H. Snow
本研究在精细结构水平上对小鼠和大鼠骨骼肌衰老过程中的肌卫星细胞进行了检测和定量。根据形态学标准，8至30个月大的动物比目鱼肌和腓肠肌中的卫星细胞的代谢活性低于未成熟肌肉中的卫星细胞。在小鼠的比目鱼肌中，卫星细胞的数量从8个月大时的4.6%下降到30个月大时的2.4%。这种减少似乎是由于在整个卫星细胞表面周围形成外部薄层材料导致一些卫星细胞进入间隙空间。
SummaryMyosatellite cells were examined and quantified at the fine structural level of resolution during aging of skeletal muscles in mice and rats. Satellite cells in the soleus and gastrocnemius muscles of animals between eight and 30 months of age appeared, according to morphological criteria, metabolically less active than those examined in immature muscles. In the soleus muscle of the mouse, satellite cells decreased in number from 4.6% at eight months of age to 2.4% at 30 months. This decrease appeared to be due to the passage of some satellite cells into the interstitial space as a result of the formation of external lamina material around the entire satellite cell surface.