Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss.
Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss.
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DOI：
10.1523/jneurosci.2845-09.2009
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发表时间：
2009-11-11
期刊：
影响因子：
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通讯作者：
Liberman MC
中科院分区：
文献类型：
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作者：
Kujawa SG;Liberman MC
对强烈的声音过度刺激会导致暂时或永久性的听力损失。暴露后阈值灵敏度的恢复被认为表明内耳微妙的机械感觉和神经结构的损伤逆转，并且对听觉功能没有持久或延迟的后果。在这里，我们表明，使用耳蜗功能测定和共聚焦成像的内耳在小鼠中，声学过度暴露引起中度，但完全可逆的，阈值升高离开耳蜗感觉细胞完整，但引起急性传入神经末梢和延迟变性的耳蜗神经。结果表明，噪声引起的耳朵损伤具有进行性后果，比传统的阈值测试所揭示的要广泛得多。这种原发性神经变性会增加在嘈杂环境中的听力困难，并可能导致耳鸣，听觉过敏和其他通常与内耳损伤相关的感知异常。
Overexposure to intense sound can cause temporary or permanent hearing loss. Post-exposure recovery of threshold sensitivity has been assumed to indicate reversal of damage to delicate mechano-sensory and neural structures of the inner ear and no persistent or delayed consequences for auditory function. Here we show, using cochlear functional assays and confocal imaging of the inner ear in mouse, that acoustic overexposures causing moderate, but completely reversible, threshold elevation leave cochlear sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the cochlear nerve. Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more widespread than are revealed by conventional threshold testing. This primary neurodegeneration should add to difficulties hearing in noisy environments, and could contribute to tinnitus, hyperacusis and other perceptual anomalies commonly associated with inner ear damage.