Specification of the meso-isthmo-cerebellar region:: The Otx2/Gbx2 boundary
Specification of the meso-isthmo-cerebellar region:: The Otx2/Gbx2 boundary
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DOI：
10.1016/j.brainresrev.2005.01.010
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发表时间：
2005-09-01
影响因子：
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通讯作者：
Alvarado-Mallart, RM
中科院分区：
文献类型：
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作者：
Hidalgo-S치nchez, M;Millet, S;Alvarado-Mallart, RM
中脑/后脑 (MH) 区域包含中脑和峡小脑原基，其特征是表达多个调控基因家族，包括转录因子（Otx、Gbx、En 和 Pax）和信号分子（Fgf 和 Wnt）。在鸟类神经管的早期阶段，这些基因呈现动态表达模式，并且仅在 HH 18-20 以后，当中脑/后脑收缩与 Otx2/Gbx2 边界重合时，它们的表达域变得更加明确。这篇综述总结了有关中脑/后脑区域规范所涉及的遗传机制的实验数据，强调了导致次级峡部组织者发现的小鸡/鹌鹑嵌合实验。 Otx2 和 Gbx2 共同调节可以确定 MH 边界的精确位置并参与峡部组织中心的感应事件特征。 (c) 2005 Elsevier B.V. 保留所有权利。
The midbrain/hindbrain (MH) territory containing the mesencephalic and isthmocerebellar primordial is characterized by the expression of several families of regulatory genes including transcription factors (Otx, Gbx, En, and Pax) and signaling molecules (Fgf and Wnt). At earlier stages of avian neural tube, those genes present a dynamic expression pattern and only at HH 18-20 onwards, when the mesencephalic/metencephalic constriction is coincident with the Otx2/Gbx2 boundary, their expression domains become more defined. This review summarizes experimental data concerning the genetic mechanisms involved in the specification of the midbrain/hindbrain territory emphasizing the chick/quail chimeric experiments leading to the discovery of a secondary isthmic organizer. Otx2 and Gbx2 co-regulation could determine the precise location of the MH boundary and involved in the inductive events characteristic of the isthmic organizer center. (c) 2005 Elsevier B.V. All rights reserved.