Aortic and Hepatic Contrast Enhancement with Abdominal 64-MDCT in Pediatric Patients: Effect of Body Weight and Iodine Dose
Aortic and Hepatic Contrast Enhancement with Abdominal 64-MDCT in Pediatric Patients: Effect of Body Weight and Iodine Dose
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DOI：
10.2214/ajr.07.3576
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发表时间：
2008-11-01
影响因子：
5
通讯作者：
Hildebolt, Charles F.
中科院分区：
文献类型：
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作者：
Bae, Kyongtae T.;Shah, Amisha J.;Hildebolt, Charles F.
OBJECTIVE.本研究的目的是回顾性评价体重和碘剂量对接受腹部和骨盆64-MDCT的儿科患者主动脉和肝脏对比增强的影响。连续87例儿科患者（50例男孩和37例女孩;中位年龄12.1岁;年龄范围3.8-17.6岁）使用64-MDCT扫描仪进行标准腹盆腔CT。使用高压注射器以2 mL/s的速度注射造影剂（350 mg I/mL），然后用15-20 mL生理盐水冲洗。根据我们的CT方案，给予的造影剂体积约为1.8 mL/kg体重，最大体积为80 mL。在造影剂注射开始后60秒开始CT扫描。测量主动脉和肝脏的CT衰减。对于每例患者，计算注射的造影剂碘质量/体重指数（g I/kg）（以下称为碘质量身体指数）。碘质量体指数与主动脉和肝脏衰减之间进行线性回归分析。观察到患者体重（19-82 kg;平均值，48.6 kg [95% CI，45.3-51.9 kg]）和造影剂体积（30-80 mL;中位数，80.0 mL）的范围很广。主动脉的中位衰减为149.0 HU（141.0-160.0 HU），肝脏的中位衰减为113.5 HU（109.5- 120.0 HU）。观察到碘质量体指数与主动脉（斯皮尔曼rho [r（s）] = 0.60 [0.45-0.72];p < 0.001）和肝（r（s）= 0.60 [0.42-0.70]; p < 0.001）衰减之间存在中度高度相关性。主动脉衰减的回归公式（58.4 ± 176.3 x碘质量身体指数[p < 0.001]）和肝衰减（58.7 + 108.5 x碘质量身体指数[p < 0.001]）表明，1.5和1.8 mL/kg（350 mg I/mL）的造影剂分别需要达到116和127 HU的肝脏造影剂增强衰减。在我们的研究中，在儿科患者中使用腹部64-MDCT，我们发现大约1.5 mL/kg或0.525 g I/kg产生116 HU的肝脏衰减或50-55 HU的肝脏增强。
OBJECTIVE. The purpose of our study was to retrospectively evaluate the effect of body weight and iodine dose on aortic and hepatic contrast enhancement in pediatric patients who underwent 64-MDCT of the abdomen and pelvis.MATERIALS AND METHODS. Eighty-seven consecutive pediatric patients (50 boys and 37 girls; median age, 12.1 years; age range, 3.8-17.6 years) underwent standard abdominopelvic CT with a 64-MDCT scanner. Contrast medium (350 mg I/mL) was injected using a power injector at 2 mL/s followed by 15-20 mL of saline flush. According to our CT protocol, the volume of administered contrast medium was approximately 1.8 mL/kg of body weight, up to the maximum volume of 80 mL. CT scanning was initiated 60 seconds after the start of the contrast medium injection. CT attenuations of the aorta and liver were measured. For each patient, the injected contrast medium iodine mass per body weight index (g I/kg) (hereafter, iodine mass body index) was calculated. Linear regression analysis was performed between iodine mass body index and aortic and hepatic attenuations.RESULTs. A wide range of patient weights (19-82 kg; mean, 48.6 kg [95% CI, 45.3-51.9 kg]) and contrast volumes (30-80 mL; median, 80.0 mL) were observed. The median attenuations were 149.0 HU (141.0-160.0 HU) for the aorta and 113.5 HU (109.5-120.0HU) for the liver. Moderately high correlations were observed between iodine mass body index and aortic (Spearman's rho [r(s)] = 0.60 [0.45-0.72];p < 0.001) and hepatic (r(s) = 0.60 [0.42-0.70]; p < 0.001) attenuations. The regression formulae for aortic attenuation (58.4 + 176.3 x iodine mass body index [p < 0.001]) and hepatic attenuation (58.7 + 108.5 x iodine mass body index [p < 0.001]) indicate that 1.5 and 1.8 mL/kg (350 mg I/mL) of contrast media are required to achieve 116 and 127 HU, respectively, of contrast- enhanced attenuation in the liver.CONCLUSION. In our study, using abdominal 64-MDCT in pediatric patients, we found that approximately 1.5 mL/kg, or 0.525 g I/kg, yields 116 HU of hepatic attenuation or 50-55 HU of hepatic enhancement.