Fire-diffuse-fire model of dynamics of intracellular calcium waves
Fire-diffuse-fire model of dynamics of intracellular calcium waves
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DOI：
10.1073/pnas.96.11.6060
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发表时间：
1999-05-25
影响因子：
11.1
通讯作者：
Pearson, JE
中科院分区：
文献类型：
--
作者：
Dawson, SP;Keizer, J;Pearson, JE
当Ca 2+从活细胞的内部储存中释放出来时，所产生的浓度增加的波可以不变形（连续传播）或以爆发式行为（跳跃式传播）传播。我们分析了“火-扩散-火”模型，以阐明这两种传播模式之间的差异。我们发现，在未成熟的爪蟾卵母细胞和心肌细胞的钙释放波是跳跃式的，而在成熟的卵母细胞的受精波是连续的。
When Ca2+ is released from internal stores in living cells, the resulting wave of increased concentration can travel without deformation (continuous propagation) or with burst-like behavior (saltatory propagation). We analyze the "fire-diffuse-fire'' model in order to illuminate the differences between these two modes of propagation. We show that the Ca2+ release wave in immature Xenopus oocytes and cardiac myocytes is saltatory, whereas the fertilization wave in the mature oocyte is continuous.