Effect of the Equipment Configuration and Operating Conditions on Process Performance and on Physical Characteristics of the Product During Coating in Spouted Bed
Effect of the Equipment Configuration and Operating Conditions on Process Performance and on Physical Characteristics of the Product During Coating in Spouted Bed
复制标题
喷动床包衣过程中设备配置和操作条件对工艺性能和产品物理特性的影响
DOI：
10.1002/cjce.5450820116
复制
发表时间：
2008
影响因子：
2.1
通讯作者：
W. P. Oliveira
中科院分区：
文献类型：
--
作者：
M. C. Publio;W. P. Oliveira
研究了喷动床包衣过程的结构和操作条件对包衣性能的影响。所分析的结构参数是导流管直径与入口孔直径之比dT/di和圆锥底角y。为了分析设备性能，测量粘附系数η和片剂质量增加速率K1作为包衣材料的质量流速W S、包衣悬浮液的质量进料流速相对于喷射气体的质量进料流速之间的比率W* s /W* g'相对于最小喷射的空气流速Q/Qms的函数，和雾化空气的进料流速W at .生长动力学的评价和测量产品的均匀性的程序。
The effects of the configuration and operating conditions on the performance of the spouted bed tablet coating process have been studied. The configuration parameters analyzed were the ratio between the draft tube diameter and the inlet orifice diameter, d T /d i , and the conical base angle, y. To analyze the equipment performance the adhesion coefficient, η, and the increase rate of the tablet mass, K 1 , were measured as a function of the mass flow rate of the coating material, W S , of the ratio between the mass feed flow rate of coating suspension relative to mass feed flow rate of the spouting gas, W* s /W* g' of the air flow rate relative to minimum spouting, Q/Q ms , and of the feed flow rate of atomising air, W at . Procedures for the evaluation of the growth kinetics and for measuring the product uniformity are presented.