CYTOPLASMIC ESTROGEN AND PROGESTERONE RECEPTORS IN PRIMARY CERVICAL-CARCINOMA - CLINICAL AND HISTOPATHOLOGIC CORRELATES
CYTOPLASMIC ESTROGEN AND PROGESTERONE RECEPTORS IN PRIMARY CERVICAL-CARCINOMA - CLINICAL AND HISTOPATHOLOGIC CORRELATES
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DOI：
10.1016/0002-9378(83)90752-4
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发表时间：
1983-01-01
影响因子：
9.8
通讯作者：
PREM, KA
中科院分区：
文献类型：
--
作者：
GAO, YL;TWIGGS, LB;PREM, KA
从1977年到1981年，用饱和点葡聚糖包被炭法测定了39例原发性宫颈癌细胞质雌激素（ERc）和孕酮（PRc）受体的存在或不存在。ERc和PRc水平与临床分期、组织学类型、组织学分级、月经状况、年龄和生存期进行比较。以ERc为5 fmol/mg， PRc为10 fmol/mg的细胞质蛋白为区分点，将肿瘤分为阳性和阴性受体组。根据Kaplan-Meier的产品极限分析计算患者的生存期。Mantel-Cox试验发现，PRc+组与PRc-组在总患者组中的生存率有统计学意义差异（P = 0.049）。当患者根据绝经状态进行分层时，仅在绝经前患者中，PRc+组与PRc-组之间的生存率存在统计学上的显著差异。
From 1977-1981, 39 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplamsic estrogen (ERc) and progesterone (PRc) receptors by a saturation point dextran-coated charcoal assay. The levels of ERc and PRc were compared with clinical stage, histologic type, histologic grade, menstrual status, age and survival. Carcinomas were divided into positive and negative receptor groups with the use of > 5 fmol/mg of cytosol protein for ERc and 10 fmol/mg of cytosol protein for PRc as discrimination points. Survival of the patients was computed by the product-limit analysis according to Kaplan-Meier. A statistically significant difference in survival in the PRc+ group vs. the PRc- group in the total group of patients was noted with the Mantel-Cox test (P = 0.049). When patients were stratified according to menopausal status, a statistically significant difference in survival was noted between the PRc+ group vs. the PRc- group in the premenopausal patients only.