Spectrum of Hepatobiliary Disease Among Children in Northeast India
Spectrum of Hepatobiliary Disease Among Children in Northeast India
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印度东北部儿童肝胆疾病谱
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Hazarika Dipankar
中科院分区：
文献类型：
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作者：
S. Narayan;M. Gautam;Hazarika Dipankar
背景：儿童肝胆疾病的疾病谱不同于成人，包括各种急慢性疾病，这些差异是由不同的因素引起的，并且因地域而异，因此有必要进行这种研究，以了解不同地区的肝胆疾病谱。目的：了解在印度东北部一家三级护理中心就诊的儿童中肝胆疾病的现有模式。材料和方法：2010年3月至2012年1月在高哈蒂医学院和医院儿科对我们在儿童肝病方面的经验进行了回顾性审核。年龄在1个月到13岁之间，有肝胆疾病症状和体征的儿童被纳入这项研究。肝胆疾病的诊断是基于临床依据和适当的实验室检查。观察与结果：70例儿童中，男孩50例(71.4%)，女孩20例(28.57%)。急性肝炎35例(50%)，新生儿胆汁淤积综合征20例(28.57%)，慢性肝病10例(14.28%)。35例急性肝炎患儿中，甲型肝炎25例(35.7%)，甲型肝炎并发急性肝功能衰竭6例(8.75%)。在10名患有慢性肝病的儿童中，有7名(70%)是由于威尔逊病。20例新生儿胆汁淤积综合征中，肝外胆道闭锁9例(12.8%)，新生儿肝炎7例(10%)，半乳糖血症4例(5.71%)。这些孩子来晚了。14例出现在4个月以后，仅4例出现在2个月前。结论：甲型肝炎感染的高发病率表明，迫切需要提高个人卫生意识，使用安全饮用水，及时接种甲型肝炎疫苗。有必要对胆汁淤积症进行早期诊断。
Background: The spectrum of hepatobiliary disorders in children is different from those of adults and include a variety of acute and chronic disorders and these variations are attributable to different factors and they vary with geographical area.Therefore, there is need of such study to find out the spectrum of hepatobiliary diseases in different areas. Aim:To find out the existing pattern of hepatobiliary disorders in children presenting at a tertiary care center in North East India. Material and methods: This hospital based retrospective audit of our experience with liver disease in children was done from March 2010 to January 2012 at Department of Pediatrics, Gauhati Medical College and Hospital. Children aged between 1 month to 13 years with signs and symptoms suggestive of hepatobiliary disorders were included in this study. Diagnosis of hepatobiliary disease was made on clinical grounds and appropriate laboratory investigations. Observation and Results:Out of 70 children, 50 (71.4%) were boys and 20 (28.57%) were girls. 35 (50%)children presented with acute hepatitis, 20 (28.57%) with neonatal cholestasis syndrome, 10 (14.28%) presented with chronic liver disease. Out of 35 children with acute hepatitis, 25 (35.7%) were because of hepatitis A. 6 (8.75%) children presented with acute liver failure due to hepatitis A infection. Out of 10 children with chronic liver disease7 (70%) were because of Wilsons disease. Out of 20 children with neonatal cholestasis syndrome, 9 (12.8%) children presented with extrahepatic biliary atresia (EHBA) and 7 (10%) children presented with neonatal hepatitis and 4 (5.71%) presented with Galactosemia. These children presented late. 14 presented after the age of 4 months, only 4 presented before the age of 2 months. Conclusion:High incidence of hepatitis A infection indicates the urgent need of increasing awareness of personal hygiene, use of safe drinking water and timely hepatitis A vaccination. There is need of early diagnosis of cholestasis.