Core Metabolic Features and Hot Origin of Bathyarchaeota
Core Metabolic Features and Hot Origin of Bathyarchaeota
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DOI：
10.1016/j.eng.2019.01.011
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发表时间：
2019-06-01
期刊：
影响因子：
12.8
通讯作者：
Wang, Fengping
中科院分区：
文献类型：
--
作者：
Feng, Xiaoyuan;Wang, Yinzhao;Wang, Fengping
古菌门深海古菌包括高度多样化的亚群，被认为是地球上最丰富的微生物之一。该门的代谢特征和进化仍然在很大程度上未知。在这篇文章中，15个新重建的和36个已发表的宏基因组组装的基因组（MAG）跨越10个亚群进行了比较代谢分析，揭示了核心代谢功能的深海古菌，即蛋白质，脂质和苯甲酸降解;糖酵解;和伍德-扬达尔（WL）途径，表明乙酰辅酶A集中代谢在这个门。此外，在特定亚群中发现了部分三羧酸（TCA）循环、产乙酸和硫相关代谢途径，表明不同亚群具有多种代谢能力和生态功能。有趣的是，大多数来自Bathy-21和-22亚群的MAG被放置在所有深海古菌谱系的系统发育根，并可能代表古老的Bathyarchaeota类型，在热液环境中被发现，并编码反向旋转酶，这表明了极端嗜热的特征。这项工作揭示了深海古菌的核心代谢特征，并表明该古菌门的热起源。(C)2019年，《The Comorers》。由爱思唯尔有限公司代表中国工程院和高等教育出版社有限公司出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
The archaeal phylum Bathyarchaeota comprises highly diversified subgroups and is considered to be one of the most abundant microorganisms on earth. The metabolic features and evolution of this phylum still remain largely unknown. In this article, a comparative metabolic analysis of 15 newly reconstructed and 36 published metagenomic assembled genomes (MAGs) spanning 10 subgroups was performed, revealing the core metabolic features of Bathyarchaeota-namely, protein, lipid, and benzoate degradation; glycolysis; and the Wood-Ljungdahl (WL) pathway, indicating an acetyl-CoA-centralized metabolism within this phylum. Furthermore, a partial tricarboxylic acid (TCA) cycle, acetogenesis, and sulfur-related metabolic pathways were found in specific subgroups, suggesting versatile metabolic capabilities and ecological functions of different subgroups. Intriguingly, most of the MAGs from the Bathy-21 and -22 subgroups, which are placed at the phylogenetic root of all bathyarchaeotal lineages and likely represent the ancient Bathyarchaeota types, were found in hydrothermal environments and encoded reverse gyrase, suggesting a hyperthermophilic feature. This work reveals the core metabolic features of Bathyarchaeota, and indicates a hot origin of this archaeal phylum. (C) 2019 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).