Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence.
Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence.
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DOI：
10.1016/s1526-0550(02)00003-3
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发表时间：
2002-06-01
影响因子：
5.8
通讯作者：
Davies, Jane C
中科院分区：
文献类型：
--
作者：
Davies, Jane C
铜绿假单胞菌是囊性纤维化（CF）肺的主要病原体。流行率很高，一旦获得，几乎总是会发生慢性感染。一些与CF潜在分子缺陷相关的假设被认为可以解释这种高患病率。这些包括导致粘膜纤毛清除受损或抗菌肽功能障碍的气道表面液体的异常、细菌受体的可用性增加、CF细胞对病原体的摄取减少以及与低水平的分子（如一氧化氮或谷胱甘肽）相关的防御受损。需要进一步的工作来确定哪些机制在感染的早期阶段是重要的。一旦微生物在CF气道中获得立足点，它们就具有广泛的特性，这些特性提高了它们的存活率，并使它们能够成功地逃避宿主防御和抗生素。转化为粘液性和形成生物膜是实现这一点的两个主要机制。了解初始感染和建立慢性化所涉及的步骤可能有助于开发新的治疗策略。
Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung. Prevalence is high and, once acquired, chronic infection will almost always ensue. Several hypotheses related to the underlying molecular defects in CF have been suggested to explain this high rate of prevalence. These include abnormalities of airway surface liquid leading to impaired mucociliary clearance or malfunction of antibacterial peptides, increased availability of bacterial receptors, reduced ingestion of pathogens by CF cells and impaired defence related to low levels of molecules such as nitric oxide or glutathione. Further work is needed to identify which of these mechanisms is important in the early stages of infection. Once the organisms have gained a foothold in the CF airway they have a wide array of properties that enhance their survival and allow them to evade host defences and antibiotic agents successfully. Conversion to mucoidy and the formation of biofilms are two of the main mechanisms by which this is achieved. Understanding the steps involved in both initial infection and in establishing chronicity may help in the development of new treatment strategies.