Acute and chronic responses of the upper airway to inspiratory loading in healthy awake humans: An MRI study
Acute and chronic responses of the upper airway to inspiratory loading in healthy awake humans: An MRI study
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DOI：
10.1016/j.resp.2007.01.008
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发表时间：
2007-08-01
影响因子：
2.3
通讯作者：
Romer, Lee M.
中科院分区：
文献类型：
--
作者：
How, Stephen C.;McConnell, Alison K.;Romer, Lee M.
我们评估了上气道对急性和慢性吸气负荷的反应。在实验I中，11名健康受试者进行了T-2加权磁共振成像（MRI）的上气道扩张肌（颏舌肌和颏舌骨肌）之前和10分钟后的压力阈值吸气肌训练（IMT）在60%的最大吸气口压（MIP）。与对照组相比，颏舌肌和颏舌骨肌的T-2值增加（p < 0.001），表明这些气道扩张肌在急性IMT时被激活。在实验II中，9名受试者在安静呼吸期间接受了上气道的2D-Flash序列MRI，同时对阻力负荷（10%，30%和50%MIP）进行单次吸气;在IMT 6周后重复该程序。在所有负荷下，上气道均出现侧向狭窄，而在负荷>= 30%MIP时，咽喉水平出现前后狭窄。使用MRI无法检测到IMT后上气道形态和狭窄的变化。(c)2007 Elsevier B. V.保留所有权利。
We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T-2-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle training (IMT) at 60% maximal inspiratory mouth pressure (MIP). T-2 values for genioglossus and geniohyoid were increased versus control (p < 0.001), suggesting that these airway dilator muscles are activated in response to acute IMT. In Experiment II, nine subjects underwent 2D-Flash sequence MRI of the upper airway during quiet breathing and while performing single inspirations against resistive loads (10%, 30% and 50% MIP); this procedure was repeated after 6 weeks of IMT. Lateral narrowing of the upper airway occurred at all loads, whilst anteroposterior narrowing occurred at the level of the laryngopharynx at loads >= 30% MIP. Changes in upper airway morphology and narrowing after IMT were undetectable using MRI. (c) 2007 Elsevier B.V. All rights reserved.