THE METABOLISM OF NICOTINE-DELTA-1'(5')-IMINIUM ION, INVIVO AND INVITRO
THE METABOLISM OF NICOTINE-DELTA-1'(5')-IMINIUM ION, INVIVO AND INVITRO
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DOI：
10.1007/bf03189632
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发表时间：
1982-01-01
影响因子：
1.9
通讯作者：
HIBBERD, AR
中科院分区：
文献类型：
--
作者：
GORROD, JW;HIBBERD, AR
尼古丁是烟草和烟草烟雾的主要成分;它被人类和实验室动物广泛代谢，产生大量代谢产物。尼古丁-Δ 1“（5”）-亚胺鎓离子，无论是作为二高氯酸盐还是盐酸盐，都被肝细胞质酶迅速转化为康尼宁。在氮气氛中孵育表明，纳入continine的O是来自H2O。在对豚鼠或大鼠腹膜内给予烟碱-Δ 1“（5”）-亚胺离子后，在酒中发现可替宁和烟碱-1“-N-氧化物。尼古丁-δ 1“（5”）-亚胺鎓离子显然是尼古丁代谢转化为可替宁的中间体。
Nicotine is a major constituent of tobacco and tobacco smoke; it is extensively metabolized by man and laboratory animals to give a large number of metabolites. Nicotine-.DELTA.1''(5'')-iminium ion, either as the diperchlorate or the hydrochloride, is rapidly converted into continine by a hepatic cytoplasmic enzyme. Incubations in an atmosphere of N indicated that the O incorporated into continine is derived from H2O. Following the i.p administration of nicotine-.DELTA.1''(5'')-iminium ion to guinea pigs or rats, cotinine, and nicotine-1''-N-oxide were found in the wine. Nicotine-.delta.1''(5'')-iminium ion is evidently an intermediate in the metabolic conversion of nicotine to cotinine.