Urinary cytokine levels in apparently healthy cats and cats with chronic kidney disease
Urinary cytokine levels in apparently healthy cats and cats with chronic kidney disease
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DOI：
10.1177/1098612x12461007
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发表时间：
2013-02-01
影响因子：
1.7
通讯作者：
Quimby, Jessica M.
中科院分区：
文献类型：
--
作者：
Habenicht, Lauren M.;Webb, Tracy L.;Quimby, Jessica M.
慢性肾脏疾病（CKD）是猫患病和死亡的常见原因。猫CKD的标志是慢性肾小管间质性肾炎，炎症有助于肾纤维化的进展。然而，目前在没有肾活检的情况下，很难直接评估肾内炎症的程度。尿液中炎症细胞因子水平的测量可以提供一种评估肾内炎症的非侵入性方法。研究人员测量了18只健康猫和26只CKD猫的尿细胞因子水平（尿细胞因子/尿肌酐比值）。当比较健康猫和CKD猫尿液中的细胞因子水平时，我们发现CKD猫尿液中的IL-8和转化生长因子- β 1 （tgf - β 1）水平显著较高，血管内皮生长因子（VEGF）水平显著较低。在CKD猫中发现血清肌酐和tgf - β 1水平显著正相关。尿细胞因子测量可能潜在地成为评估CKD猫肾内炎症、纤维化和血管健康的有用手段。
Chronic kidney disease (CKD) is a common cause of illness and death in cats. The hallmark of CKD in cats is chronic tubulointerstitial nephritis, and inflammation contributes to the progression of renal fibrosis. However, at present, it is difficult to assess directly the degree of intra-renal inflammation without renal biopsy. Measurement of inflammatory cytokine levels in urine may provide a non-invasive means of assessing intra-renal inflammation. Urine cytokine levels (urine cytokine/urine creatinine ratio) were measured in 18 healthy cats and 26 cats with CKD. When urine cytokine levels in healthy and CKD cats were compared, we found significantly higher levels of IL-8 and transforming growth factor-beta 1 (TGF-beta 1) in urine of CKD cats, along with significantly lower vascular endothelial growth factor (VEGF) levels. A significant positive correlation between serum creatinine and TGF-beta 1 levels was found in CKD cats. Urinary cytokine measurement may, potentially, be a useful means of assessing intra-renal inflammation, fibrosis and vascular health in cats with CKD.