Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts
Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts
复制标题
DOI：
10.1016/j.ejphar.2009.05.011
复制
发表时间：
2009-08-01
影响因子：
5
通讯作者：
Lu, Lin
中科院分区：
文献类型：
--
作者：
Shi, Jie;Jun, Wang;Lu, Lin
雷帕霉素的哺乳动物靶点是一种进化上保守的丝氨酸 - 苏氨酸激酶（mTOR），它根据环境信号控制蛋白质的合成和分解代谢。这项随机双盲临床试验招募了60名戒毒的海洛因成瘾者，并将他们随机分为三组：安慰剂组、2.5毫克雷帕霉素组和5毫克雷帕霉素组。参与者接受线索反应范式，暴露于中性和与毒品相关的图像5分钟，同时评估暴露前后的渴望程度、焦虑程度、血压和心率。我们发现与毒品相关的线索增加了戒毒海洛因成瘾者的渴望和焦虑程度，但对血压和心率没有影响。单次高剂量的雷帕霉素显著降低了由与毒品相关线索引起的渴望，但没有降低焦虑。我们的研究结果表明，雷帕霉素作为一种潜在的药物疗法，对于预防由与毒品相关线索引起的渴望复发值得进行门诊临床试验。（C）2009爱思唯尔有限公司。保留所有权利。
The mammalian target of rapamycin is an evolutionarily conserved serine-threonine kinase (mTOR), which controls protein synthesis and catabolism in response to environmental cues. This randomized double-blind clinical trial enrolled 60 abstinent heroin addicts and randomly assigned them to three groups: placebo, 2.5 mg and 5 mg rapamycin. The participants were given the cue-reactivity paradigm with 5 min exposures to neutral and drug-related imagery while craving, anxiety, blood pressure and heart rate pre- and post-exposure were assessed. We found that drug-related cues increased both craving and anxiety of abstinent heroin addicts, and had no effect on blood pressure and heart rate. A single high-dose of rapamycin significantly reduced the craving, but not anxiety induced by drug-related cues. Our findings suggested that rapamycin merits outpatient clinical trials as a potential pharmacotherapy for relapse prevention from drug-related cue induced craving. (C) 2009 Elsevier B.V. All rights reserved.