Prognostic significance of tumour markers in endometrial cancer
Prognostic significance of tumour markers in endometrial cancer
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DOI：
10.1159/000218037
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发表时间：
1997-07-01
期刊：
影响因子：
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通讯作者：
Ngan, HYS
中科院分区：
文献类型：
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作者：
Lo, SST;Cheng, DKL;Ngan, HYS
对100例正常人、47例妇科良性疾病患者和97例子宫内膜癌患者的血清癌抗原（CA） 125、CA15.3、CA19.9、癌胚抗原和组织多肽抗原进行了分析。肿瘤患者个体肿瘤标志物（bbb2sd）升高的发生率为21.5-30.9%。CA125和CA15.3的升高与预后不良的临床因素显著相关。单因素分析显示，CA125、CA15.3和CA19.9升高与较短的生存期显著相关。在多变量分析中，CA15.3具有高度显著性，且具有较大的风险比。综上所述，CA15.3是判断子宫内膜癌患者预后的有效指标。
Serum cancer antigen (CA) 125, CA15.3, CA19.9, carcinoembryonic antigen and tissue polypeptide antigen were analyzed in 100 normal subjects, 47 patients with benign gynaecological diseases and 97 patients with endometrial cancer. The incidence of individual elevated tumour markers (>2SD) was 21.5-30.9% in cancer patients. Elevations of CA125 and CA15.3 were significantly associated with poor prognostic clinical factors. Univariate anaylses showed that elevated CA125, CA15.3 and CA19.9 were significantly associated with shorter survival. In multivariate analyses, CA15.3 was highly significant and had a larger hazard ratio. In conclusion, CA15.3 is a useful marker for the prognosis of patients with endometrial cancer.