Correlation between morphological heterogeneity and genetic alteration within one tumor in adenocarcinomas of the lung
Correlation between morphological heterogeneity and genetic alteration within one tumor in adenocarcinomas of the lung
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DOI：
10.1046/j.1440-1827.2000.01134.x
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发表时间：
2000-11-01
影响因子：
2.2
通讯作者：
Inai, K
中科院分区：
文献类型：
--
作者：
Yamasaki, M;Takeshima, Y;Inai, K
在一些人类癌症中，人们主张在形态学和遗传分析的基础上进行多步致癌作用。在肺腺癌中，最近提出了从非典型腺瘤性增生（AAH）到细支气管肺泡癌（BAC）和/或更恶性的腺癌的致癌过程。在本研究中，我们选择了13个肺肿瘤，其外围具有AAH样或BAC样区域，其他部位具有低分化区域，并检查了它们在染色体3p、9p和17p上的杂合性丢失（LOH）和p53基因的点突变。在 13 例病例中，有 5 例检测到 LOH 和/或 p53 基因点突变的异质模式，并且在分化较差的区域频繁发生遗传改变。这些发现表明，一些肺腺癌是通过多步癌变发生的。
In some human cancers, multistep carcinogenesis has been advocated on the basis of morphological and genetic analysis. In adenocarcinoma of the lung, a carcinogenetic process from atypical adenomatous hyperplasia (AAH) to bronchiolo-alveolar carcinoma (BAC) and/or more malignant adenocarcinoma has been recently suggested. In the present study, we selected 13 lung tumors which had AAH-like or BAC-like areas at the periphery, and poorly differentiated areas at other sites, and examined their loss of heterozygosity (LOH) on chromosome 3p, 9p and 17p and point mutation of the p53 gene. A heterogeneous pattern of LOH and/or point mutation of the p53 gene was detected in five of 13 cases, and genetic alterations were frequent in the areas of poorer differentiation. These findings suggest that some adenocarcinomas of the lung occur through multistep carcinogenesis.