Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.
Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.
复制标题
DOI：
10.1099/mic.0.001084
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Schniete JK
中科院分区：
文献类型：
--
作者：
Undabarrena A;Pereira CF;Kruasuwan W;Parra J;Sélem-Mojica N;Vind K;Schniete JK
去年，英国微生物学会支持的维基式倡议 ActinoBase 发表了一篇评论，重点介绍了放线菌界特别感兴趣的研究。在这里，我们提出了第二次 ActinoBase 综述，展示了 2020 年和 2021 年初发布的精选报告，整合了放线菌领域的观点。放线菌因其产生特殊代谢物的无与伦比的能力而闻名，其中许多代谢物被用作具有抗菌、抗真菌或免疫抑制活性的治疗剂。进行了大量研究来了解这些代谢物在环境中的用途，无论是在群落内还是在宿主相互作用中。此外，人们在开发计算工具来处理大数据、简化实验设计和寻找新的生物合成基因簇优先策略方面做出了许多努力。此外，合成生物学还提供了先进的工具来阐明这些代谢物的生物合成。此外，在了解丝状放线菌发育周期及其代谢调节的基本原理方面仍有待揭开的谜团。本综述的重点是使用综合方法论和方法来了解放线菌生物学的更大图景的研究，涵盖四个研究领域：i）技术和方法； ii) 专门的代谢物； iii) 开发和监管； iv) 生态和宿主相互作用。
Last year ActinoBase, a Wiki-style initiative supported by the UK Microbiology Society, published a review highlighting the research of particular interest to the actinomycete community. Here, we present the second ActinoBase review showcasing selected reports published in 2020 and early 2021, integrating perspectives in the actinomycete field. Actinomycetes are well-known for their unsurpassed ability to produce specialised metabolites, of which many are used as therapeutic agents with antibacterial, antifungal, or immunosuppressive activities. Much research is carried out to understand the purpose of these metabolites in the environment, either within communities or in host interactions. Moreover, many efforts have been placed in developing computational tools to handle big data, simplify experimental design, and find new biosynthetic gene cluster prioritisation strategies. Alongside, synthetic biology has provided advances in tools to elucidate the biosynthesis of these metabolites. Additionally, there are still mysteries to be uncovered in understanding the fundamentals of filamentous actinomycetes' developmental cycle and regulation of their metabolism. This review focuses on research using integrative methodologies and approaches to understand the bigger picture of actinomycete biology, covering four research areas: i) technology and methodology; ii) specialised metabolites; iii) development and regulation; and iv) ecology and host interactions.